慢性淋巴细胞性甲状腺炎与HLA-DQ位点基因的相关性分析

http://www.100md.com 《中华内科杂志》 1998年第6期

     徐春白耀崔莲仙郭芝生张如胜戴为信 100730 中国医学科学院、中国协和医科大学北京协和医院内分泌科(徐春、白耀、郭芝生、张如胜、戴为信)，基础医学研究所医学分子生物学国家重点实验室(崔莲仙) 中华内科杂志 1998 0 37 6

    关键词： 期刊 zhnkzz 0 甲状腺炎，自身免疫性HLA-DQ抗原聚合酶链反应 fur -->

【摘要】目的分析汉族慢性淋巴细胞性甲状腺炎(CLT)与HLA-DQ位点基因多态性的相关性。方法用序列特异性引物的聚合酶链反应(PCR-SSP)方法，分析30例由病理证实的我国汉族CLT患者及24名正常对照的外周血白细胞基因组DNA的HLA-DQA₁及DQB₁位点的基因多态性分布。结果在CLT组中，DQA₁*0301的等位基因频率显著高于对照组(P<0.02，RR=7.00)，而DQB₁*0602的频率则明显低于对照组(P<0.01，RR=0.095)。结论 HLA-DQA₁*0301可能与CLT的易感性相关，而DQB₁*0602可能与CLT的抗性相关，在HLA-DQ位点存在有易感及抗性的双重作用，等位基因之间的共同作用可能是影响CLT发生的重要因素之一。

Analysis of HLA-DQ genes in 30 patients of Han nationality with chronic lymphocytic thyroiditis Xu Chun ^ , Bai Yao, Cui Lianxian, et al. ^ Department of Endocrinology, Peking Union Medical College Hospital, Beijing 100730

【 Abstract 】 Objective To evaluate the association of HLA-DQ polymorphism with chronic lymphocytic thyroiditis (CLT) in Chinese Han nationality. Methods HLA-DQA₁ and DQB₁ gene polymorphism was tested in 30 CLT patients and 24 normal controls of Chinese Han nationality by using DNA amplification with polymerase chain reaction of sequence-specific primers (PCR-SSP). Results The allele frequency of DQA₁ *0301 was higher in CLT patients than that in normal controls (P<0.02, RR=7.00), while the allele frequency of DQB₁ *0602 was lower in CLT patients than that in normal controls (P<0.01, RR=0.095). Conclusion DQA₁ *0301 was probably the susceptible gene and DQB₁ *0602 the resistant gene for CLT, so both susceptability and resistance for CLT were present in HLA-DQ gene locus.

【 Key words 】 Thyroiditis, autoimmune HLA-DQ antigens Polymerase chain reaction

慢性淋巴细胞性甲状腺炎(CLT)是一种器官特异性自身免疫性疾病 ......

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