江文枢 陆启民 潘国章 530001 南宁，广西壮族自治区民族医院外科 中华肝脏病杂志 1998 0 0 3


    关键词：肝细胞癌 p53基因 复发 来源 期刊 zhgzbzz 0 肝癌专栏 fur -->


    

【摘要】 目的 进一步研究肝细胞癌(HCC)术后复发的来源。方法 采用聚合酶链反应—限制性片段长度多态性分析和免疫组化技术，以p53基因型作为标志物，结合癌组织AFP的表达，对17例复发的HCC的来源进行了研究。结果 10例术后第1年复发的HCC中，7例初发病灶与再发病灶来源相同，3例来源不同。7例术后第2年复发的HCC中，3例初发病灶与再发病灶来源相同，4例来源不同。结论 HCC术后复发具有两种起源，一是单中心起源；二是某种致癌机制的作用，使HCC术后仍可反复产生新的肿瘤。因此，HCC术后必须采取综合性的治疗措施来减少术后的复发。

    

ORIGINS OF POSTOPERATIVERECURRENT HEPATOCELLULAR CARCINOMA

Jiang Wenshu, Lu Qimin, Pan Guozhang. Guangxi National Hospital, Nanning 530001

【Abstract】 Objective To study further origins of postoperativerecurrent hepatocellular carcinoma(HCC). Methods Origins of 17 cases ofrecurrent HCC were studied by polymerase chain reaction-restriction fragment lengthpolymorphisms (PCR-RFLP) and immunohistochemistry techniques. The elements which westudied included the codon 249 mutation in exon 7 of p53 gene, the p53 protein and the AFPin the cancer tissue. Results By comparing the recurrent tumors withtheir primary tumors, it was found that 7 of 10 cases of recurrent HCC in the first yearafter resection were monocentric in origin, and the other 3 cases were multicentric; 3 of7 cases of recurrent HCC in the second year after resection were monocentric in origin,and 4 cases were multicentric. Conclusion The study results indicate thatthe majority of early recurrent HCC are generated from a single tumor cell (unicentricorigin); because of the action of some carcinogen mechanism, HCC may occur repeatedly inaddition to recurrence from residual cancer cells, even after a radical resection.

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