生秀杰 宋和存 何秀琴 110001 沈阳，中国医科大学第一临床学院妇科 中华肿瘤杂志 1998 0 0 5


    关键词：子宫内膜肿瘤 细胞凋亡 基因，bcl-2 基因表达 免疫组织化学 期刊 zhzlzz 0 临床研究 fur -->


    

【摘要】 目的 探讨抗凋亡基因bcl-2与子宫内膜癌的关系。方法 应用免疫组化链霉菌-抗生物素过氧化物酶染色法，检测15例子宫内膜非典型增生及50例子宫内膜腺癌的石蜡包埋标本中bcl-2基因的表达。结果 子宫内膜非典型增生组织中，bcl-2蛋白高表达，子宫内膜腺癌中bcl-2低表达(P<0.05)。在子宫内膜腺癌中，随着临床分期的升高、组织病理分级的降低及肌层浸润的加深，bcl-2表达阳性率逐渐下降(P<0.05)。结论 bcl-2可能与子宫内膜组织的异常增殖有关，并主要在早期起作用。

    Bcl-2 gene expression in endometrial carcinoma Sheng Xiujie, Song Hecun,He Xiuqin.The First Clinical College,China Medical University,Shenyang 110001

    【Abstract】 Objective To evaluate the relationship between bcl-2 gene andendometrial carcinoma. Methods Immunohistochemical staining was performed on formalin-fixed paraffin-embedded tissue sections. A monoclonal antibody to the bcl-2 geneproduct was used, the signal was detected using a streptavidin-biotin complex with aminoethylcarbazole. There were 15 cases of endometrial atypical hyperplasia and 50 casesof endometrial carcinoma examined. Results Bcl-2 expression was high in endometrialatypical hyperplasia, whereas bcl-2 expression was low in endometrial carcinoma. Inendometrial carcinoma, with progression of clinical stage, decreased histologic grade anddeepening of cancer invasion, the positive rate of bcl-2 expression was correspondinglydecreased. Conclusion Bcl-2 plays a role in the genesis of endometrial carcinomaespecially at the initial stage.

     ......