邓安梅 仲人前 陈孙孝 张玲珍 施笑梅 孔宪涛 邓安梅 仲人前 陈孙孝 张玲珍 施笑梅 孔宪涛 上海第二军医大学附属长征医院 中华肝脏病杂志 1999 0 7 3


    关键词：肝脏疾病 抗原，CD28 共刺激 期刊 zhgzbzz 0 临床研究 fur -->


    

摘要 目的 了解肝病患者中细胞毒性T细胞异常免疫激活的机理。 方法 采用流式细胞技术检测了不同类型肝病患者外周血单个核细胞(peripheral blood mononuclear cell，PBMC)中T淋巴细胞亚群的共刺激分子CD28的表达情况。 结果 慢性肝炎活动期患者中CD28⁺ ，CD8⁺ CD28⁺ T细胞比正常对照组显著下降，而肝硬化、肝癌及慢性肝炎缓解期组与正常对照组无显著差异。 结论 提示B7-CD28共刺激在慢性肝炎活动期的肝损伤中起作用。

    

Elimination of CD28⁺ T cell in patients with chronic active hepatitis

DENG Anmei, ZHONG Renqian, CHEN Sunxiao, et al.

    Clinical Immunology Center, Changzheng Hospital, Shanghai 200003

Abstract Objective To study the role of toxicyte T cell in active hepatitis. Methods We examined CD28⁺ T cell in patients with chronic active/remission hepatitis by flow cytometry. Results It shows that CD28⁺ , CD8+CD28⁺ T cell in patients with chronic active hepatitis decreased significantly, compared with normal control or patients with liver cirrhosis and heptoma. Conclusion It implies that B7-CD28 costimulation pathway contribute to the tissue injury in hepatitis.

     ......