李玉莉 陈华江 何金 杜宇欣 李玉莉、陈华江、何金 200003上海，第二军医大学长征医院病理科；杜宇欣 包头市第三人民医院病理科 中华骨科杂志 1999 0 19 1


    关键词：骨肿瘤；纤维瘤；结缔组织增生；病理学；临床 期刊 zhgkzz 0 骨肿瘤 fur -->


    

【摘要】目的 探讨骨成纤维性纤维瘤(DF)的临床病理特点、组织发生、临床误诊及复发因素。方法收集11例骨成纤维性纤维瘤病例，男6例，女5例，年龄11～42岁。免疫组织化学ABC法标记SMactin，Desmin，Vimentin，NSE，S-100蛋白，α-AT(α-平滑肌肌动蛋白)及Lysozgme。结果Vimentin阳性11例，Desmin阳性9例、弱阳性2例，SMactin阳性10例、弱阳性1例，NSE、S-100蛋白、α-AT及Lysoagmo均阴性。3例复发，4例病理性骨折，11例术前无一例诊断DF。结论DF含肌纤维母细胞，此种细胞在组织学上具有平滑肌和纤维母细胞特征。造成临床误诊与复发的主要原因是缺乏特征性的临床表现及X线表现，肿瘤无包膜。作者发现瘤细胞具有沿骨小梁及哈佛管侵袭性生长的生物学行为，与肿瘤复发有直接相关性。

    Study of Clinical andPathological Features of Desmoplastic Fibroma of Bone

LI Yuli, CHEN Huajiang, HE Jing,etal.

    Department of Pathology, Changzheng Hospital, Shanghai 200003

【 Abstract 】 Objective Thepathological features of desmoplastic fibroma (DF) in bone and its pathogenesis,recurrence as well as the cause of misdiagnosis were analysed. Methods Eleven cases of DF were studied, including 6 females and 5 males,with a range of 11 to 42years. Immunohistochemical studies have been used to evaluate the patterns ofimmunoreactivity of DF. Results Immunohistochemical stains of DF showedthat 11 cases were positive for Vimentin, 9 cases were positive for Desmin (2 cases wereslight positive), 10 cases were positive for SMactin (1 case is slight positive). All werenegative for NSE, S- 100protein, α- AT, lysozyme. Three cases recured,4 cases occured pathological fracture. Eleven cases DF werenot diagnosed before operation. Conclusions DF contains myofibroblasts,featuring both smooth muscle cells and fibroblasts. Radiologically and clinically, DF is atypical, which is liable to recur and to be misdiagnosed. The tumor without capsuleinvades along bone trabecula and Haversian system. As a result, the aggressive behavior ofthis tumor was closely related to its recurrence.

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