朱元喜 郝希山 孙慧 王庆生 300060 天津，天津市肿瘤医院 中华肿瘤杂志 1999 0 21 4


    关键词：乳腺肿瘤；β-胡萝卜素；小鼠 期刊 zhzlzz 0 基础研究 fur -->


    

【摘要】 目的 观察β-胡萝卜素(BC)对移植性乳腺癌(MA₇₃₇ )生长、荷瘤小鼠生存期及对CMF(CTX、MTX、5-Fu)化疗毒副作用的影响。方法 采用TAⅡ小鼠移植性乳腺癌模型，荷瘤小鼠给予BC和(或)CMF不同处理。结果 (1)BC组、BC+CMF组平均每只小鼠生存时间较对照组显著延长，CMF组小鼠因化疗毒性其生存时间较对照组明显缩短。(2)除CMF组小鼠在实验7天内全部死亡外，BC组、BC+CMF组在实验不同时期肿瘤体积均明显小于对照组。(3)长期单独灌喂BC小鼠均未出现毒副作用。(4)CMF组小鼠在第2次化疗后逐渐出现严重的毒副作用，并在第3次化疗后全部死亡；而BC+CMF组小鼠在第3次化疗后体重略有减轻，未出现其他不良症状，且在化疗后4～5天内体重恢复到治疗前水平。结论 BC可显著抑制MA₇₃₇ 的生长，延长宿主的生存期，并且对CMF化疗产生的毒副作用有明显的缓解作用，且长期灌喂安全、无毒。

Effect of β -carotene on mouse transplantablemammary cancer MA₇₃₇

ZHU Yuanxi, HAO Xishan, SUN Hui, et al.Tianjin Institute & Hospital, Tianjin 300060

【Abstract】 Objective Tostudy the effect of β-carotene (BC) on the growth of MA₇₃₇ in TAⅡ mice. Methods BC(250 mg/kg) dissolved in vegetable oil was given per os by gavage once every other day.Mice were treated with BC alone or in combination with chemotherapy (CMF protocol).Control mice were given solvent vehicle. Tumor volume and survival period of the treatedand control mice were recorded.Results In mice treated with BC alone,the growth of the tumor was retarded, but the tumor inhibitory effect was more marked inmice treated with BC+CMF (growth inhibition rate: 49.1% versus 60.5%). The therapeuticeffect of combined use of BC and CMF was only slightly better than that of CMF alone.However, BC helped alleviate toxic side effects of the chemotherapeutic drugs so that thesurvival period was significantly prolonged in the BC+CMF treated mice. Long termtreatment with β-carotene was without side effect.Conclusion β-caroteneinhibits tumor growth, prolongs survival and alleviates toxic side effects of chemotherapyin a mouse mammary cancer model.

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