马英 张定凤 秦波 于成银 范开 400010 重庆医科大学附属第二医院病理科(马英、于成银)；重庆医科大学病毒性肝炎研究所(张定凤、秦波、范开) 中华肝脏病杂志 1998 0 0 1


    关键词：乙型肝炎病毒 Fas Fas配体 凋亡 期刊 zhgzbzz 0 临床研究 fur -->


    

【摘要】 目的 研究Fas/FasL表达与HBV感染的关系。 方法 用免疫组化方法同时检测52例肝穿组织Fas、FasL、HBsAg和HBcAg的表达。 结果 这四项指标均与病变进展程度相关，其表达的阳性程度在各型乙型肝炎的分布差异均有显著意义(P<0.05或P<0.01)，但Fas/FasL阳性的肝细胞并不全为HBsAg及HBcAg阳性。 结论 Fas/FasL系统参与HBV感染时的细胞凋亡机制，但可能存在某种自杀方式或自分泌及旁分泌杀伤机制。

    

STUDY OF THE RELATIONSHIPBETWEEN THE EXPRESSION OF FAS/FAS LIGAND AND THE HBV INFECTION

Ma Ying, Zhang Dingfeng, QinBo, et al. Pathology Department, The Second Hospital, Chongqing Medical University,Chongqing 400010

【Abstract】 Objective To studythe relationship between the expression of Fas/Fas Ligand and HBV infection. Methods 52cases of liver biopsies were studied by immunohistochemistry to determine Fas, FasL, HBsAgand HBcAg. Fas/FasL were double stained. Results These 4 components were significantly correlated with the severityof inflammation, and the degree of the expression of Fas/FasL, HBsAg, HBcAg on hepatocyteshad distinct difference in different hepatitis (P<0.05 or P<0.01). But not allpositively-expressed Fas/FasL hepatocytes were positive for HBsAg and HBcAg. Conclusion Fas/FasLsystem was involved in the mechanism of hepatocyte apoptosis of hepatitis B, But,probably, there were autocrine or paracrine and fratricide mechanisms mediated by thehepatocytes themselves in viral hepatitis B.

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