刘小平 宋少柏 徐文通 王殿军 赵海潞 韦立新 100853 北京，解放军总医院 中华肿瘤杂志 1999 0 21 6


    关键词：血管生成；血管内皮细胞生长因子；肿瘤内微血管密度；结直肠肿瘤/外科学；预后 期刊 zhzlzz 0 临床研究 fur -->


    

【摘要】 目的 探讨血管生成与结直肠肿瘤的发生、发展关系，评估微血管计数(MVD值)及血管内皮细胞生长因子(VEGF)表达与结直肠肿瘤预后的相关性。方法 应用免疫组化法回顾性地研究了32例结直肠肿瘤石蜡包埋的病理组织。结果 正常粘膜、腺瘤、癌组织的MVD值递增。不同病理状态下的结直肠癌MVD值有差异，VEGF阴性组MVD值低于VEGF阳性组，低MVD值组及VEGF阴性组生存率高于高MVD值组及VEGF阳性组。结论 结直肠肿瘤血管生成在其恶变、生长、转移等方面是至关重要的，血管生成(包括VEGF状态)对判断直肠肿瘤转移及预后有重要参考价值。

Microvesselquantitation and expression of VEGF in colorectal tumors

LIU Xiaoping, SONG Shaobai, XU Wentong, et al. Department of GeneralSurgery, Department of Pathology, General Hospital of PLA, Beijing 100853

【Abstract】 Objective To evaluateangiogenesis in colorectal tumorigenesis and to assess the prognostic significance ofmicrovessel quantitation and VEGF status. Methods Thirty two colorectal carcinomas, 5adenomas and 10 normal mucosa were studied imunohistochemically for microvessels andexpression of VEGF. Results The mean vascular density (MVD) was 11±4 in normal mucosa,28±11 in adenomas, and 50±22 in carcinomas (normal versus adenomas P>0.05; normalversus carcinomas P<0.01; adenomas versus carcinomas P<0.05 ). MVD varied with tumorcell differentiation and tumor stage, but the differences were not significant. Theexpression of VEGF is closely associated with angiogenesis. Both MVD and VEGF expressionwere associated with prognosis. Conclusion VEGF status and MVD are of prognosticsignificance in colorectal cancer patients.

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