笪冀平 石怀银 陆江阳 100036 北京，空军总医院病理科(笪冀平)；解放军总医院病理科(石怀银)；解放军第三○四医院病理科(陆江阳) 中华肿瘤杂志 1999 0 21 4


    关键词：甲状腺肿瘤/病理学；癌，鳞状细胞/病理学；预后 期刊 zhzlzz 0 临床应用 fur -->


    

【摘要】 目的 研究伴有胸腺样成分(carcinomashowing thymus-like element，CASTLE)甲状腺癌的组织发生、形态学和生物学特性，以区别于一般鳞状细胞癌。方法 分析患者的临床资料，包括主要体征、手术记录及生存时间，并复习全部病理切片。结果 伴有CASTLE的甲状腺癌不同于鳞癌，不仅有典型的鳞状分化特点，亦伴有胸腺分化特征，如哈氏小体、淋巴上皮样结构和间质淋巴组织增生；CASTLE的预后较其他鳞癌为佳，本组病例中位生存期为10.5年。结论 重新认识具有CASTLE特征的甲状腺癌，为临床治疗和判断预后提供帮助。

Thyroid squamous-cell carcinoma showing thymus-like element (CASTLE): a report of eight cases

DA Jiping, SHI Huaiyin, LU Jiangyang. Air Force General Hospital of PLA,Beijing 100036

【Abstract】 Objective To report 8 cases of squamous-cell carcinoma showing thymus-like element (CASTLE) of the thyroid. Methods Clinicaldata and pathological sections were retrospectively reviewed.Results CASTLEof the thyroid differed from ordinary squamous-cell carcinoma (SCC) in that it not onlypresented typical squamous pattern of differentiation, but also admixed with thymicarchitecture, such as Hassall′s corpuscles, lymphoepithelial-like structure and maturelymphocyte infiltration in the stroma. CASTLE of the thyroid had much better prognosisthan that of the ordinary SCC of the thyroid with a median survival time of 10.5 year.Histogenesis of CASTLE was discussed. Conclusion Thyroid CASTLE is ofrare occurrence. It should be distinguished from SCC of thyroid in order to treat suchpatients adequately.

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