冯继锋 郑秀立 戴爱娣 吴剑秋 210009 南京市，江苏省肿瘤防治研究所 江苏省肿瘤医院内科 中华肿瘤杂志 1998 11 0 6


    关键词：乳腺肿瘤/药物疗法；表阿霉素/治疗应用；环磷酰胺/治疗应用；氟脲嘧啶/治疗应用 期刊 zhzlzz 0 临床研究 fur -->


    

【摘要】 目的 评价高剂量表阿霉素(HD-EPI)合并环磷酰胺(CTX)、氟脲嘧啶(5-Fu)治疗进展期和晚期乳腺癌的安全性和有效性。方法 对32例可评价的Ⅲ、Ⅳ期乳腺癌患者静脉给予CTX600 mg/m² 、EPI 90 mg/m² ～110 mg/m² 、5-Fu 900 mg/m² ，每21天重复。并与30例非同期低剂量组比较(EPI为50mg/m² )。结果 高剂量组的总有效率为71.9%，完全缓解率为12.5%，明显高于低剂量组(56.7%和6.7%)；初治的有效率(80.0%)略高于复治者(68.2%)。全组中位缓解期7.4个月，中位生存期12.5个月。白细胞减少为主要的毒副反应，发生率为89.5%(68/76)，Ⅲ、Ⅳ度分别为27.6%和18.4%；胃肠道毒性为轻、中度，未见明显的心肝肾毒性。结论 HD-EPI+CTX+5-Fu方案治疗晚期乳腺癌安全有效，可在临床进一步试用。

A clinical report of high-doseepirubicin combined with cyclophosphamide and fluorouracil for advanced breast cancer Feng Jifeng, Zheng Xiuli, Dai Aidi, et al. Department ofMedical Oncology, Jiangsu Cancer Hospital, Nanjing 210009

     【Abstract】 Objective To evaluate safety and efficacy of high-dose epirubicin combined withcyclophosphamide and fluorouracil for advanced breast cancer. Methods Thirty two cases with stage Ⅲ and Ⅳ breastcancer were treated with epirubicin (EPI) 90～110 mg/m² , cyclophosphamide (CTX) 600 mg/m² and5-fluorouracil (5-Fu) 900 mg/m² every 21 days. The therapeutic effect wascompared with that in patients treated with low-dose EPI( 50 mg/m² ).Results The response rate (RR) inpatients treated with high-dose EPI was 71.9% (CR=4, PR=19) which was significantly betterthan that in the low-dose EPI-treated patients (CR=2, PR=5). The therapeutic effect wasslightly better in patients initially diagnosed than in patients in recurrence (RR: 80% vs68.2%) the median remission and surriving peroid was 7.4 months and 12.5 months,respectively. The major side effect was leukopenia. Mild to moderate GI tract side effectswere obsevved. There was no significant cardiotoxicity. Conclusion High-dose EPI combined with CTX, 5-Fu is a safe andeffective regimen for patients with advanced breast cancer worthy of further clinicaltrial.

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