黄德清 丁吉元 曹永成 左金良 张云昌 250031济南，济南军区总医院骨病科(黄德清、张云昌),病理科(丁吉元，曹永成)；泰安医学院第二附属医院骨科(左金良) 中华骨科杂志 1999 0 19 5


    关键词：椎板切除术；硬膜；粘连；移植；同种 期刊 zhgkzz 0 基础研究 fur -->


    

【摘要 】目的通过动物实验观察预防硬膜外粘连的有效材料和方法。方法56只大白兔随机分为4组。切除L5椎板后造成12mm×5mm硬脊膜裸露区，A组不用任何间置物覆盖，B组充填质量分数为2%的透明质酸钠,C组用酒精保存的异体硬脊膜覆盖，D组用透明质酸钠充填后再用硬脊膜覆盖。术后2、4、8、12周进行肉眼及光镜观察，8周还行硬膜外粘连等级评定及计算机图像分析。结果A组硬膜外形成致密粘连，B、C组部分粘连，D组无明显粘连。结论保存硬脊膜与透明质酸钠联合应用为预防椎管内粘连最为有效的方法。

    An Experimental Study onPrevention of Peridural Adhesion After Laminectomy

HUANG Deqing^* ,DING Jiyuan,CAOYongcheng,et al.

    ^* Department of Orthopaedics,General Hospital of Jinan Command,Jinan 250031

【Abstract 】 Objective An experimentalstudy to find out effective substances and methods for the prevention of periduraladhesion.Methods Laminectomy was performed in lumbar 5 segment in 56 rabbits which weredivided into 4 groups.12 mm× 5 mm dura mater was exposed, and left uncovered in groupA,covered with 2%(m/m)sodium hyaluronate in group B, with alcohol stored allogenic duramater in group C,with both above materials in group D.The specimens were observed grosslyand histologically at 2,4,8 and 12 weeks postoperatively.Classification and computedimaging analysis of epidural adhesion were also done at 8 weeks.Results Severe periduraladhesion were formed in group A,less adhesion formed in group B and C,no obvious adhesionformed in group D. Conclusion Stored dura mater combined with sodium hyaluronate has thebest preventive effect on peridural adhesion after laminectomy.

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