李恩孝 李蓉 张珍华 王剑波 710061 西安医科大学第一临床医学院肿瘤内科(李恩孝、李蓉、张珍华)；第四军医大学病理教研室(王剑波) 中华肿瘤杂志 1998 0 0 5


    关键词：乳腺肿瘤 P-糖蛋白 免疫组织化学 预后 期刊 zhzlzz 0 临床研究 fur -->


    

【摘要】 目的 研究P-糖蛋白(P-gp)在乳腺癌组织中的表达及其临床意义。方法 用免疫组化法检测60例乳腺癌、19例转移性乳腺癌组织P-gp表达及化疗疗效。结果 乳腺癌P-gp表达阳性率为48.3%，P-gp表达与年龄、月经状态、腋淋巴结转移数目、分期、病理组织类型及激素受体状况无关(P>0.05)。P-gp阳性组远处转移率(62.1%)及死亡率(51.7%)高于阴性组(16.1%及12.9%，P<0.005)，5年生存率(48.3%)低于阴性组(87.1%，P<0.05)。阳性组辅助化疗后远处转移率(94.7%)高于阴性组(57.1%，P=0.0468)。转移性乳腺癌P-gp阳性组化疗有效率(1/10)低于阴性组(7/9，P=0.0055)。结论 免疫组化法检测P-gp表达对评估乳腺癌多药耐药、化疗疗效及预后具有一定临床价值。P-gp阳性者对MDR型药物耐药，疗效及预后差。

    Clinical significance of P-glycoprotein expression in breast cancer Li Enxiao, Li Rong, Zhang Zhenhua, et al. Department of Medical Oncology, The First Clinical MedicalCollege, Xi'an Medical University, Xi'an 710061

    【Abstract】 Objective To study the clinical significance of P-glycoprotein (P-gp) in breast cancer. Methods Expression of P-gp in 60 cases of breast cancer wasexamined by immunohistochemistry. P-gp expression and response to chemotherapy werecomparatively investigated in 19 patients with metastatic breast cancer. Results The P-gp was positive in 48.3% of the 60 cases of breast cancer. P-gp expression was notrelated to patients′ age, menstruation status, number of axillary lymph nodes involved,clinical stage, histological type, and hormonal receptor status(P>0.05). The frequencyof metastasis (62.1%) and mortality (51.7%) were higher in P-gp positive cases than thosein negative cases (16.1% vs 12.9%, P<0.005). The 5-year survival rate of P-gp positivecases (48.3%) was significantly lower than that of negative cases (87.1%) (P<0.05). Inpatients received adjuvant chemotherapy distant metastasis occurred more frequently in P-gp positive cases (94.7%) than in P-gp negative cases (57.1%) (P=0.0468). More P-gpnegative patients (7/9) than positive patients (1/10) were responsive to chemotherapy(P=0.0055). Conclusion Immunohistochemical examination of P-gp expression is useful inpredicting response to chemotherapy and prognosis in breast cancer patients. P-gppositivity is associated with poor prognosis.

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