石胜军 吴坤莹 510515 广州，第一军医大学病理生理教研室 中华整形烧伤外科杂志 1998 0 0 3


    关键词：烧伤；休克；一氧化氮；微循环 期刊 zhzxsswkzz 0 论 著 fur -->


    

【摘要】 目的 探讨NO在烧伤休克发病中的作用及机制。方法 采用大鼠40%体表面积深Ⅱ度烫伤模型，观察NO合成酶抑制剂L-NAME和NO合成前体L-Arg对动物平均动脉压、肌肉微循环、血浆中NO^- ₂ /NO^- ₃ 浓度和存活时间的影响。结果 烧伤后NO合成增多，同时平均动脉压下降，肌肉微循环紊乱；抑制NO生成可提升血压，但却加重微循环紊乱，加速动物死亡；促进NO合成则明显改善微循环，延长动物存活时间。结论 NO大量合成是机体在烧伤早期的一种保护性反应。

    Protective role of endogenous nitric oxide to microcirculation of rats during burn shock Shi Shengjun,Wu Kunying.Department of Pathophysiology,The First Military Medical University,Guangzhou,510515

    【Abstract】 Objective To investigate the role of nitric oxide (NO) in burn shock.Methods A model of 40% TBSA deep Ⅱ burn injury in rats was used.The effects of L-NAME,the inhibitor of NO synthase,and L-Arg,the precursor of NO synthesis,on the mean arterial pressure (MAP),microcirculation of muscle,concentration of NO^- ₂ /NO^- ₃ in plasma and the survival time of animals were observed.Results The results showed that the synthesis of nitric oxide was increased significantly,accompanied with the decrease of MAP and the disturbances of microcirculation of muscle after burn.L-NAME inhibited the decrease of MAP,but aggravated the disturbances of microcirculation and shortened the survival time of animals,while L-Arg produced the contrary effects.Conclusion The results indicated that the large amount of NO in blood after burn may play an early protective role to injury.

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