关键词：肥厚性瘢痕；裸鼠；胶原酶；胶原降解
【摘要】 目的 观察胶原酶对肥厚性瘢痕(HTS)胶原降解的影响，探讨它对HTS的治疗作用。方法 建立HTS裸鼠移植模型，局部注射胶原酶于瘢痕组织。治疗后取材行光、电镜观察和分析。结果 HTS组织胶原纤维被降解，真皮层变薄，瘢痕缩小，质地变软，与对照组差异十分明显。结论 胶原酶的局部注射可能是治疗HTS的较好方法。
The effect of intradermalinjection of collagenase in implanted hypertrophic scar in nude mice
WU Jixiang* , CHENDeying, WU Zongyao. Department of Physical Medicine and Rehabilitation, SouthwestHospital, Third Military Medical University, Chongqing 400038
【 Abstract 】 Objective Effects of collagen degradation in hypertrophic scar by intradermal injection ofcollagenase were observed. Methods Hypertrophic scar was implanted intonude mice and collagenase was injected locally. Light and electron microscopicobservations were carried out. Results Collagen degradation inhypertrophic scar by intradermal injecton of collagenase was observed. The implanted scarsbecame soft, thin and small. Conclusion These results suggested thatlocal injection of collagenase may be a useful therapeutic tool for hypertrophic scar.
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