杨松林 何清濂 林子豪 刘麒 袁湘斌 刘宁飞 赵耀忠 200003 上海第二军医大学长征医院整形科 中华整形烧伤外科杂志 1998 0 14 2


    关键词：γ干扰素；瘢痕；成纤维细胞 期刊 zhzxsswkzz 0 论著 fur -->


    

    本课题受国家自然科学基金资助

     【摘要】 目的 探讨瘢痕成纤维细胞生物学活动的调控因素。方法 以瘢痕成纤维细胞为研究对象，观察基因重组γ干扰素(下简称IFN-γ)对瘢痕组织中成纤维细胞的生长增殖、胶原合成及其重构等生物学活动的影响。结果 IFN-γ可以抑制瘢痕成纤维细胞的生长增殖、胶原合成以及胶原纤维凝胶的收缩。结论 表明IFN-γ是创伤修复与瘢痕形成过程中的一种负性调节因子，有望在病理性瘢痕的防治中发挥重要作用。

    The biological effects of IFN-γ on scar-derived fibroblasts Yang Songlin,He Qinglian,LinZihao,et al.Department of Plastic Surgery,Changzheng Hospital,The Second Military MedicalUniversity,Shanghai 200003

     【Abstract】 Objective The biological activities of fibroblasts are themain cellular activities in scar formation.However,the fibroblasts are modulated by manyfactors. Investigating these factors is important to understanding scar formation.Methods This study focused on the effects of recombinantinterferon-r(IFN-γ) on the growth,collagen biosynthesis of fibroblasts and thecontraction of fibrobalast-populated collagen lattices.Results Theresults showed that rIFN-γ not only could reduce thegrowth and collagen synthesis of scar-derived fibroblasts,but also inhibit the contractionof fibroblast-populated collagen lattices. Conclusion The authors confirmthat IFN-γ is a cytokine with down-regulation effecton scar formation,and suggest that rIFN-γ can play animportant role in the prevention and treatment of scars.

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