李春 谢家伦 卢汉平 510080 广州， 中山医科大学第一附属医院小儿外科 中华小儿外科杂志 1998 0 0 5


    关键词：尿道下裂；雄激素不敏感综合征；雄激素受体；雌激素受体 期刊 zhxrwkzz 0 论 著 fur -->


    

摘要 目的：探索先天性尿道下裂与阴茎皮肤细胞雄激素受体(AR)、 雌激素受体(ER)的表达及细胞核内的聚集的关系。方法：通过受体的放射配基结合分析， 对28例不同程度的先天性尿道下裂患儿外生殖器皮肤细胞内的AR、ER的表达及细胞内的分布进行了测定。结果：实验显示尿道下裂患儿外生殖器皮肤细胞内及胞核内AR量较正常对照减少(P<0.01)，尿道下裂的严重程度与细胞内及细胞核内的AR量无关(P>0.05)。细胞内总ER与正常无显著性差异(P>0.05)，胞核内ER量较正常对照减少(P<0.05)。结论： AR异常是先天性尿道下裂的原因之一，先天性尿道下裂也属于雄激素不敏感综合征的范畴， 而核内ER的减少可能为继发性改变。

    Androgen and Estrogen Receptors in Prepuce ofChildren with Hypospadias Li Chun, Xie Jialun, Lu Hanping. Dept. of Pediatric Surgery, First Affiliated Hospital of Sun YatsenMedical University, Guangzhou 510080

    Abstract Objective: To study the relationship between androgen receptors(AR)and estrogen receptors(ER) in cells and nuclei of prepuce in patients with hypospadias andthe severity of hypospadias. Methods: AR and ER expression and its distribution in thepreputial cells of 28 cases with different types of hypospadias were examined byradioligand binding assay(RBA). Results: The total cellular and nuclear AR concentrationsin prepuce of hypospadias patients were lower than those of control group (P<0.01). There was no correlation between the severity of hypospadiasand the cellular and nuclear levels of AR (P>0.05).There was no statistically significant difference in cellular ER between the hypospadiaspatients and the control group (P>0.05). The nuclearER in hypospadias patients was lower than that of control (P<0.05). Conclusions: Abnormality of AR is a contributing factor inthe pathogenesis of hypospadias. Hypospadias may be a manifestation of androgeninsensibility syndrome. Reduced level of nuclear ER may be a secondary change.

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