李小松 张金哲 李小松(北京，首都医科大学附属北京儿童医院外科 100045)张金哲(北京，首都医科大学附属北京儿童医院外科 100045) 中华小儿外科杂志 2000 0 21 1


    关键词：生长抑素；肠套叠；放射免疫测定 期刊 zhxrwkzz 0 40-42 临床研究 fur -->


    

摘 要：目的 探讨血浆生长抑素含量在小儿原发性肠套叠发病及病理发展中的变化和作用。方法 采用放射免疫测定法，测定41例原发性肠套叠患儿血浆生长抑素含量值，并与60例正常儿和12例肠梗阻患儿进行比较。结果 血浆生长抑素含量在生后3个月达到峰值，之后逐渐下降。肠套叠组血浆生长抑素量在灌肠组、麻醉组、手术组依次升高，灌肠组平均值低于正常对照组，麻醉组和手术组均高于正常对照组，肠梗阻组血浆生长抑素含量则明显高于其他各组。结论 原发性肠套叠发病及病理发展过程中存在血浆生长抑素含量的规律性变化，其含量可作为判定肠套叠病理变化程度的指标，此变化可能在肠套叠发病及病理发展过程中起一定作用，并从理论上提出生长抑素类似物应用于肠套叠辅助治疗的可行性。

    Plasma somatostatin levelsin intussusception

LI Xiaosong, ZHANG Jinzhe

    (Department of Surgery, Beijing Children's Hospital, Beijing 100045, China)

Abstract： Objective To study the levels of plasmasomatostatin throughout the course of intussusception.Methods Post-prandial plasma somatostatinconcentrations were measured with radioimmu noassay in 41 patients with intussusception,12 patients with intestinal obstruction and 60 normal controls. Patients withintussusception were subdivided into air reduction, anaesthetic and operative groups. Results In the normal control group, theplasma somatosta tin level peaked at 3 months of age and declined thereafter. The plasmasomatost atin was lowest in the air reduction group, higher in the anaesthetic group andhighest in the operative group. The plasma somatostatin level of the former group wassignificantly lower than that of the controls whereas the levels of the latter two groupswere higher than that of the controls. The highest level was recorded in patients withintestinal obstruction.Conclusions Plasma somatostatin is implicated in the process ofintussusception and can be used as a marker of the process. Somatostatin a nalogue may bepotentially useful in non-operative management of intussusception.

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