许贻白 王贤军 诸金水 王亚仙 王庄 313000 浙江湖州市第二人民医院 中华神经科杂志 1999 0 32 1


    关键词：脂蛋白类；LDL；一氧化氮；脑缺血 期刊 zhsjkzz 0 论著 fur -->


    

【摘要】 目的 研究急性缺血性脑卒中患者血浆氧化低密度脂蛋白(oxLDL)与一氧化氮(NO)的关系及它们在缺血性脑卒中发病机制中的作用。方法 测定45名健康体检者、20例动脉硬化患者和75例急性缺血性脑卒中患者血浆LDL及体外氧化获得的oxLDL对血小板聚集功能和NO水平的影响。结果 动脉硬化和脑卒中患者血浆oxLDL值均明显升高，提示血浆LDL及oxLDL对血小板聚集有明显的促进作用，同时降低NO水平；血小板聚集的增强和oxLDL呈正相关，和NO呈负相关，而和LDL水平无相关性。结论 脑卒中和动脉硬化患者LDL对氧化修饰的易感性增加，氧化修饰的LDL通过激活血小板、灭活NO而促进动脉粥样硬化，易致血栓形成。因此，抗氧化治疗在脑卒中和动脉硬化的防治中有重要意义。

    Interaction of plasma oxidized low density lipoprotein with nitric oxide inpathogenesis of ischemic stroke XU Yibai, WANG Xianjun, ZHU Jinshui,et al.Huzhou Second Municipal Hospital, Huzhou 313000

    【Abstract】 Objective To investigate the interaction ofplasm oxidized low density lipoproptein (oxLDL) with nitric oxide(NO) in pathogenesis ofischemic stroke. Method The effect of plasma LDL and oxidize modifiedLDL in vitro in 45 healthy controls, 20 patients with atherosclerosis and 75 patients withacute ischemic stroke on platelet aggregation and NO level was determined. Results The plasma LDL and oxLDL of patients significantly enhanced platelet aggregation anddecreased the level of NO simultaneously.The increase in platelet aggregation was relatedto the concentrations of plasma oxLDL positively and to the levels of NO negatively. Butno relation between platelet aggregation and plasma LDL. Conclusion TheLDL of patients with atherosclerosis and ischemic stroke is more susceptible to oxidativemodification and the oxidized LDL can activate platelet and inactivate NO.These activitiesmay promote atherosclerotic thrombosis and development of ischemic stroke.

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