徐金枝 杨明山 李保华 姜海平 张润希 徐沙贝 武汉，同济医科大学附属同济医院神经科 430030 中华神经科杂志 1999 0 32 6


    关键词：重症肌无力；；临床研究 期刊 zhsjkzz 0 论著摘要 fur -->


    

【摘要 】 目的 研究重症肌无力(MG)的临床特点。方法 回顾性分析1956～1998年间诊治的2385例MG病例资料。结果 本组MG患者性别差异较小(男∶女=1∶1.01)，发病年龄以儿童期为主(47.8%)，以眼睑下垂首发者多见(77.4%)，按改良Osserman分型以Ⅰ型为主(60.1%)，危象发生率低(8.1%)，激素中剂量冲击、小剂量维持疗法和胸腺切除术疗效好。结论 本组病例的临床资料与国外报道有较大差异，提示我国MG的临床特点有其独特之处，充分认识其临床特点将有助于临床的诊断和治疗。

Myasthenia gravis： clinical study in 2 385 patients

XU Jinzhi, YANG Mingshan, LI Baohua, et al.

    Department of Neurology, Tongji Hospital, Tongji Medical University, Wuhan 430030

【 Abstract 】 Objective To study the clinicalcharacteristics of myasthenia gravis(MG). Methods Retrospective study was done on 2 385 patients who werediagnosed at Tongji Hospital from 1956 to 1998. Results (1) There waslittle difference of morbidity of MG between the male and the female MG patients. The sexratio was 1∶1.01 M∶ F,but in the onset age group of20～ 40 years old,therewere more female patients than male ones,and the male ones were more common in thepatients with their onset after 40 years old. (2)The average onset age was 17.7 years old,and the most common onset age group was between the youngest to nine years old. Themorbidity decreased as the age of onset got older. (3)The extraocular muscles are mostfrequently involved as the first symptom of MG. According to the modified Osserman′s criteria, 1 434 patients(60.1%) were classified as groupⅠ . The patients in groupⅡincreased with the age of onset getting older. (4)Thymectomy was performed in 124 patients, only one thymoma was present in 85 cases and 4malignant thymomas were found in 4 cases ......