李善宗 胡学强 广州，中山医科大学附属第一医院神经科 510080 中华神经科杂志 1999 0 32 6


    关键词：多发性硬化；；人类白细胞抗原；基因分型；；聚合酶链反应 期刊 zhsjkzz 0 论著摘要 fur --> /literature/clinic/diagnose/diagnose02.asp?keyword=多发性硬化；；人类白细胞抗原；基因分型；；聚合酶链反应


    

【摘要 】 目的 分析多发性硬化遗传易患的分子免疫遗传背景。方法 采用聚合酶链反应-序列特异性引物(PCR-SSP)联合技术对45例病例组和105例正常对照组人类白细胞抗原DRB1基因(HLA-DRB1)进行基因分型。结果 病例组HLA-DR2基因频率高于正常对照组，优势比为3.321，有统计学意义(P<0.01)。结论 HLA-DR2基因与多发性硬化遗传易患相关联，提示可能还存在保护性基因。

Correlation betweenHLA-DRB1 alleles and hereditary susceptibility in multiple sclerosis

LI Shanzong, HU Xueqiang.Department of Neurology, the First Affiliated Hospital of Sun Yat sen University ofMedical Sciences. Guangzhou 510080

【 Abstract 】 Objective To analyze the hereditarysusceptibility for HLA-DRB1 alleles to multiple sclerosis (MS) patients. Methods To type the alleles of HLA-DRB1by PCR-SSP technology in 45 MS patients and 105 normal controls. Results The frequency of HLA-DR2 gene inthe MS group was higher than that in the normal control group and associated with theonset of the disease significantly (Odds Ratio 3.321, P<0.01). Conclusions HLA-DR2 was the associated geneof hereditary susceptibility for MS and some protective genes might be present.

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