【摘要】 目的 探讨慢性肺心病患者血浆D-二聚体等纤溶指标变化。方法 对42例肺心病患者治疗前后及20例对照组的血浆纤溶活性分别进行测定。结果 血浆D-二聚体水平在肺心病加重期患者明显升高(与对照组和缓解期比较P<0.001)；血浆纤溶酶活性在肺心病加重期明显下降；血浆纤溶酶活性与二氧化碳分压(PaCO₂ )呈负相关(r=-0.43，P<0.01)，与氧分压(PaO₂ )呈正相关(r=0.39，P<0.01)。结论 血浆纤溶活性降低与肺心病高凝状态有关，并容易导致肺小动脉血栓形成，D-二聚体可作为慢性肺心病肺小动脉血栓形成的实验室指标。慢性肺心病患者临床上可应用溶栓药物。

    

Clinical study offibrinolysis indicators in patients with chronic pulmonary heart disease

GUO Liping, WANG Baofa, XIAO Lanying, et al.

    Department of Respiratory Disease, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000

【Abstract】 Objective To investigate thechange of D-dimer and other fibrinolysis indicators in patients with chronic pulmonaryheart disease. Methods The fibrinolytic activity of plasma was measuredin 42 patients with chronic pulmonary heart disease and in 20 controls (matched with sexand age ). Results The D-dimer level was significantly higher inexacerbated patients than in controls (P<0.001); The fibrinolytic activity in patientswas lower than in controls. The plasma fibrinolytic activity was positively correlatedwith PaO₂ and negativly correlated with PaCO₂ . Conclusions Thedepressed fibrinolysis may be associated with hypercoagulability state of chronicpulmonary heart disease and contributes to thrombi in small pulmonary arteries andarterioles. D-dimer can be used in diagnosis of thrombi formation in small pulmonaryarteries and arterioles. Patients with chronic pulmonary heart disease can be treated withfibrinolysis drugs.

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