帕金森病非痴呆和痴呆患者载脂蛋白E基因型分析
帕金森病||痴呆||载脂蛋白E||基因,关键词：
100730 北京医院神经内科(秦斌、曾湘豫、蔡晓杰、陈海波、张文记、郑剑辉、许贤豪、王新德)；卫生部老年医学研究所生化室(国汉帮、唐蔚青)；河南省漯河市第二人民医院内科(吕杰民)
关键词：帕金森病；；痴呆；；载脂蛋白E；；基因
【摘要】 目的 探讨帕金森病(PD)和帕金森病痴呆(PDD)患者的载脂蛋白E基因频率及表型分布与PDD发病的关系。方法 对PD组(36例)和PDD组(32例)的临床资料进行回顾性分析，并设正常非痴呆对照组(60例)，比较三组载脂蛋白E的基因频率及表型的分布。结果 PD、PDD和正常非痴呆对照组都以Apo Eε3基因频率最常见,约占93%，ApoE ε4和ε2基因频率三组相比差异无显著意义。三组ApoE基因表型分析发现E3/3型最为常见，含E4或E2基因频率表型差异无显著意义。结论 PDD发病与ApoE ε4或ε2基因频率无关,推论PDD与AD发病机制不同。
Analysis of apolipoprotein E in Parkinson′s disease with and without dementia Qin Bin , Zeng Xiangyu, Guo Hanbang, et al. *Department of Neurology, Beijing Hospital， Beijing 100730
【Abstract】 Objectives To study thegenotypes vs phenotypes of apolipoprotein E(ApoE) between the Parkinson′s disease without dementia (PD) group and with dementia (PDD)group. Methods The clinical data of the Parkinson′s disease without PD and with PDD dementia groups (36 cases and 32cases) and the non-dementia control group (60 cases) were respectively and comparallystudied. The distribution of the genotypes vs phenotypes of ApoE in the three groups werealso identified. Results The genotype of ApoE ε3 was more predominant (accounting for 93.0%) in PD. PDD andnon-dementia centrol groups without the difference of the genotype of ε4 and ε2. The phenotype ofApoE 3/3 was more common in PD, PDD and non-dementia control groups without the differenceof the phenotypes including E4 and E2. Conclusion Therewas no correlationship between the PDD and ApoE ε4and ε2, suggesting that the pathogenesis of PDD wasquite different from that of AD.
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