【摘要 】 目的 研究血管内皮生长因子(以下简称VEGF)表达与肺癌的预后相关性。方法 应用SP免疫组化方法研究VEGF在60例肺癌患者组织中的表达。结果 VEGF阳性表达率为60%，VEGF阳性表达主要出现在肺癌组织中癌细胞胞浆内，VEGF表达与肺癌的淋巴结转移、复发有关：其中N1、N2(+)组VEGF阳性率分别为53%、80%，高于N0组(23%，P<0.01)，VEGF阳性表达率在肺癌复发组(80%)高于无复发组(53%，P<0.05)；3、5年生存率VEGF(+)与VEGF(-)组分别为31%、11%和88%、50%；术后生存时间VEGF表达(+)组远低于VEGF表达(-)组(分别为31±7月,64±7月,P<0.05)。结论 VEGF是促进肺癌组织血管生成的关键因素，是预测肺癌患者预后的重要指标。

    

REN Yingchun, LI Xiangjiu, ZHANG Jinhua

Department of Thoracic Surgery, Hebei Chest Hospital, Shijiazhuang 050041

【Abstract 】 Objective Todetermine the association between the expression of vascular endothelial growth factor (VEGF) and prognosis of lung cancer. Methods Apply the SP immunohistochemistry stainmethod to investigate the expression of VEGF in 60 specimens of patients with lung cancer,who had undergone curative resection more than 36 months before. Results The VEGF stainpositive rate is 60% in 60 cases of lung cancer specimens； The immunoreactivity of VEGFwas almost exclusively restricted to the tumor cells, the positive expression of VEGFshowed significantly higher in the patients with lymph node metastasis and/or relapse. Thepositive rates of VEGF were higher in N1, N2 groups (53%, 80%) than in No group (23%,P<0.01), and in relapse group (80%) than in non-relapse group (53%, P<0.05).Postoperative survival time was shorter in VEGF(+) group (31±7 months) than in VEGF(-)group (64±7 months, P<0.05). The 3, 5 year survival rates showed significantdifference between VEGF(+) (31%, 11%) and VEGF(-) (88%, 50%) groups. Conclusions Theresults suggest VEGF is a reliable prognostic parameter and antiangiogenesis therapy willbe a useful strategy in treatment of the human lung cancer.

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