【摘要 】 目的 观察卡铂(C)、氟尿嘧啶(F)化疗加放射治疗(放疗)对中晚期非小细胞肺癌(NSCLC)的疗效。方法 选择中晚期NSCLC80例随机入CF+放疗和单纯放疗组，两组病例均给予常规放疗，CF+放疗组放疗第1、4周给予化疗，卡铂100mg、氟尿嘧啶500 mg静脉滴注，每周连用5天。结果 近期疗效完全缓解率CF+放疗组为48%，单纯放疗组为25%，1、3、5年生存率CF+放疗组分别为63%、38%和18%，较单纯放疗组的40%、15%和8%有明显提高，CF+放疗组毒副反应主要是Ⅰ、Ⅱ度骨髓抑制和消化道反应。结论 卡铂、氟尿嘧啶化疗结合放疗，能提高NSCLC的疗效及生存率。

    

QIAO Tiankui, XIN Li, LIU Haiyan

Taishan Medical College Hospital, Taian 271000

【Abstract 】 Objective Toobserve the effect of combined chemotherapy (carboplatin and fluorouracil) withradiotherapy for moderate and advanced non-small cell lung cancer. Methods Eightypatients with moderate and advanced non-small cell lung cancer were randomized into 2groups,radiotherapy group(R) and carboplatin,fluorouracil plus radiotherapy group(CF+R).All patients in two groups received conventional radiotherapy.Patients in CF+R groupreceived combined chemotherapy with carboplatin(100 mg, d 1-5)、5-fluorouracil(500 mg d1-5) in the first and fourth weeks during radiotherapy. Results The complete responserate was 48% in CF+R group, 25% in R group. The 1-year, 3-year, 5-year survival rates were63%, 38%,18% in CF+R group,and 40%, 15%, 8% in R group. The major toxic reactions in CF+Rgroup were grade Ⅰ～Ⅱ myelo-suppression and digestive tract reaction. Conclusions Combinedchemotherapy(carboplatin and fluorouracil)with radiotherapy is preferable for non-smallcell lung cancer.

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