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关键词：肺肿瘤；肿瘤标记，生物学
【摘要】 目的 探讨血清糖链抗原CA242、组织多肽抗原(TPA)、神经元特异性烯纯化酶(NSE)、及癌胚抗原(CEA)联合测定对肺癌的诊断价值。方法 应用酶联免疫法(ELISA)对120例肺癌、31例肺结核及30名健康人血清进行观察。结果 (1)4项指标在不同组织类型肺癌中均有不同程度升高且明显高于肺结核组及健康对照组。(2)CA242对肺癌的敏感性分别为腺癌(AC)65%、鳞癌(Sq)41%及小细胞肺癌(SCLC)32%，特异性为93%。(3)综合评价肺癌组2项同时阳性者AC为79%、Sq54%及SCLC63%,而结核组假阳性率仅为7%，健康组未发现假阳性者。结论 4项指标对不同组织类型肺癌均有一定诊断价值，联合测定时可以提高对肺癌的阳性诊断，CA242可作为一项新的肺癌标志物应用。
The diagnostic values ofCA242 combining other tumor markers for lung cancer
ZHANG Shucai, MA Yu, YANG Xinjie, et al. Beijing TB and ThoracicTumor Research Institute, Beijing 101149
【Abstract】 Objective Toinvestigate the diagnostic values of CA242, TPA, NSE and CEA tumor markers for lungcancer. Methods Using enzyme-linked immunosorbent assay(ELISA). Theserum levels of four markers in lung cancer, TB patients and normal subjects (NOR) weremeasured. Results Serum concentrations of CA242, TPA, NSE and CEA weresignificantly higher in patients with lung cancer than patients with TB andNOR(P<0.01). The sensitivities of CA242 were 65% for adenocarcinoma (AC), 41% forsquamous cancer (Sq) and 32% for SCLC, respectively; the specificity was 93%. Thesensitivities of NSE were 33%(AC), 41%(Sq) and 71%(SCLC), respectively; the specificitywas 97%. The sensitivities of TPA were 65%(AC), 69%(Sq) and 61%(SCLC), respectively; thespecificity was 93%. The sensitivities of CEA were 72%(AC), 54%(Sq) and 55%(SCLC),respectively; the specificity was 93%. Using two tumor markers the positive rates were79%(AC), 54%(Sq) and 63%(SCLC), respectively; the false positive rates in TB and NOR were7% and 0%, respectively. Conclusions Assessing several markers can helpdifferentiating various histological type of lung cancer and can increase significantlythe sensitivity and specificity. It is clinically more useful than single markerevaluation. CA242 can be used in diagnosis of lung cancer.
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