【摘要】 目的 探讨肿瘤坏死因子(TNF)与多发性肌炎/皮肌炎(PM/DM)发病机理的关系。方法 用双抗体夹心ELISA法检测了24例PM/DM患者和18例正常人TNFα水平，并分析了其与临床相关实验室指标的关系。结果 18例正常人血清中未测出TNFα，而24例患者中9例TNFα水平升高。可测出TNFα的PM/DM患者组与未测出患者组比较前者具有：①高尿肌酸水平(P〈0.01)；②低尿肌酐水平(P〈0.05)；③血沉高(P〈0.01)；血清肌酶两者之间未见明显差异。结论 TNFα水平与PM/DM的活动性相关，TNFα可能在PM/DM的发病机理中起着重要作用。

    Study on the Serum Level of Tumor Necrosis Factor- α and Its Relationship with SomeClinical Parameters in Polymyositis/Dermatomyositis Gu Lihong,Liang Zaifu,Zhang Shifa,et al.Department of Dermatology,No.1 Hospital of China Medical University,Shenyang 110001

【Abstract 】 Objective To study the relationship between tumor necrosis factor(TNF)and the pathogenesis of polymyositis/dermatomyositis(PM/DM).Methods The serum levels ofTNF- α were determined in 24 patients with PM/DM and 18 normal controls by doubleantibody sandwich ELISA method,and then their relationship with some clinically relatedlaboratory parameters was analyzed. Results The results showed that the TNF- α was notdetected in the control group, and the level of TNF- α was increased in 9 of 24 patients withPM/DM. In comparison with the group with elevated TNF- α to the group without, we found the group with elevated TNF- α had: (1) a higher level of urinary creatine (P 〈0.01). (2) a lower level of urinary creatinine(P 〈0.05). (3) increased level of ESR (P 〈0.01). (4) no difference in serum levels of CPK, LDH and AST. Conclusion Our results indicate that there is a relationship between TNF- α level and the disease activity of PM/DM, and TNF- α may play an important role in the pathogenesis of PM/DM.

    【Key words 】 Polymyositis Dermatomyositis Tumor necrosis factor

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