肾病综合征_血栓栓塞_高凝状态(期刊论文)

肾病综合征合并肺血栓栓塞三例

http://www.100md.com 《中华结核和呼吸感染》 1999年第3期

肾病综合征|血栓栓塞|高凝状态,关键词：

     王莞尔陆慰萱谢满红 100081 北京，解放军第四六六医院呼吸科(王莞尔、谢满江)；中国医学科学院中国协和医科大学北京协和医院呼吸内科(陆慰萱) 中华结核和呼吸感染 1999 0 22 3

    关键词：肾病综合征；血栓栓塞；高凝状态期刊 zhjhhhxgr 0 论著 fur -->

【摘要】目的 提高对肾病综合征(NS)合并肺动脉血栓栓塞(PTE)的认识。方法对3例NS合并PTE患者进行回顾性分析。结果 NS合并PTE时，血纤维蛋白原、α₂球蛋白、血脂均增高。肾脏病理检查1例患者为膜性肾病。肺灌注通气显像及尸检显示：双肺多发栓塞1例。应用肝素钠和(或)尿激酶治疗有效。结论 NS时存在血液高凝状态，易并发PTE。故对NS高度怀疑PTE时，应做肺动脉造影检查。在应用糖皮质激素的基础上抗凝溶栓联合治疗效果最佳。

    A retrospective study of 3 cases of nephrotic syndrome with pulmonarythromboembolism ^WANG Waner, LU Weixuan, XIE Manhong. ^ The466th Hospital of PLA, Beijing 100081

    【Abstract】 Objective To study the nephrotic syndrome (NS)with pulmonary thromboembolism (PTE). Methods 3 cases of NS with PTEwere reviewed. Results The fibrinogen (mean 7.8 g/L),alpha-2-maccoglobulin (mean 21%) and cholesterol (mean 7.2 mmol/L) in the blood werehigher in the NS patients with PTE. 1 of 2 patients was found to be membranousnephropathy. Ventilation/perfusion lung scan and a postmortem examination showed thatbilateral, multiple pulmonary thromboembolism was found in 1 case. It was effective to useheparin and/or urokinase for NS with PTE. Conclusions NS exists in thehypercoagulable state in blood. It is easy to concomit PTE. Pulmonary artery angiogramshould be done when NS with PTE was suspected. Besides glycocorticoids, the combination ofanticoagulants and thrombolysis gave most favorable results for NS patients with PTE.

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