关键词:病原体;死亡相关因素;肺感染
【摘要 】 目的 探讨继发性免疫抑制患者(ICH)肺部感染的病原体分布及影响预后的相关因素。方法 对1986年12月~1996年12月期间经病原学和(或)病理学确诊的ICH并发肺部感染80例进行回顾性分析。结果 病原体(除巨细胞病毒)分布:普通细菌45例(56%),结核杆菌23例(29%),真菌9例(11%),卡氏肺囊虫3例(4%)。ICH并发肺部感染的病死率,年龄<60岁为48%,≥60岁为67%,并发菌血症的病死率为86%,无菌血症的病死率为45%,白细胞计数>10×109 /L和<4.0×109 /L的病死率分别为67%,87%,(4.0~10)×109 /L病死率为23%,弥漫性病灶和局限性病灶病死率分别为65%和23%(P<0.05,P<0.01)。ICH并发肺部感染的病死率在年龄、有无菌血症、白细胞计数高低、病灶累及范围方面差异有显著性。病死率在性别、基础疾病、病原体种类、混合感染方面差异无显著性(P>0.05)。结论 细菌是ICH肺部感染最常见的病原体之一,在我国ICH肺结核的激活和复燃应引起足够重视。
Analysis of etiological agents anddeath-relating factors of pulmonary infections in immunocompromised patients Qu Jieming ,He Lixian ,Li Xiying ,et al. Department ofPulmonary Medicine,Zhongshan Hospital, Institute of Respiratory Diseases, Shanghai MedicalUniversity, Shanghai 200032
【Abstract 】 Objective To explorethe distribution of etiological agents and death-relating factors of pulmonary infectionsin immunocompromised hosts(ICH). Method 80 patients of pulmonary infections in ICH confirmed by etiologicaland(or)pathological diagnosis were retrospectively analyzed. Result The distribution of etiological agents of pulmonary infections(except for cytomegalovirus, CMV): common bacteria 56%, mycobacterium tuberculosis 29%、fungus 11%,pneumocystis carinii 4%. Mortality of pulmonaryinfections in ICH showed significant difference between age 67%(≥60 years):48%(<60 years),bacteremia 86%(yes) :45%(no), white blood cell count67%, 87%(>10×109 /L, <4.0×109 /L):23%(4.0~10)×109 /L ......
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