周晓光 杨杰 杨琳琳 吴婕翎 510010 广州，广东省妇幼保健院新生儿科(周晓光，杨杰，杨琳琳)；广东省新生儿护理抢救中心(吴婕翎) 中华围产医学杂志 1999 0 0 1


    关键词：黄疸；新生儿；葡糖醛酸酶 期刊 zhwcyxzz 0 论 著 fur -->


    

【摘要】 目的 探讨β-葡萄糖醛酸苷酶(β-GD)与母乳性黄疸的关系，以及母乳和粪便β-GD测定在母乳性黄疸诊断上的意义。 方法 采用酶学比色法对47例母乳性黄疸及60例正常新生儿母乳及粪便β-GD活性浓度进行测定，并分析母乳及粪便β-GD活性浓度测定在母乳性黄疸患儿的阳性率。 结果 黄疸组母乳及粪便β-GD活性浓度(1.363±0.299U/L及1.071±0.297 U/L)较正常组(0.746±0.325 U/L及0.496±0.276 U/L)明显增高，两组之间具有极显著差异(P<0.001)。两组母乳β-GD测定的阳性率分别为66.0%与8.3%，差异有显著性意义(P<0.01)。其灵敏度、特异度、阳性预测值、阴性预测值及诊断正确率分别为66.0%、91.7%、86.1%、77.5%及80.4%。两组粪便β-GD测定的阳性率分别为68.1%与6.7%，差异有显著性意义(P<0.01)。其灵敏度、特异度、阳性预测值、阴性预测值及诊断正确率分别为68.1%、93.3%、88.9%、78.9%及82.2%。 结论 β-GD活性浓度与母乳性黄疸的发生、发展密切相关，母乳与粪便β-GD测定对母乳性黄疸的诊断具有一定实用价值。

    Diagnostic Values of β -glucuronidase Measurement forBreast Milk Jaundice in Neonates

Zhou Xiaoguang,Yang Jie,YangLinlin,et al.Department of Neonatology,Maternal and Child Health Hospital of GuangdongProvince,Guangzhou ,510010

【 Abstract】 Objective To study the relationship between β -glucuronidase(β -GD) and breast milk jaundice and the diagnostic vaules ofbreast milk and fecal β -GDmeasurement for breast milk jaundice in neonates. Methods Milk and fecal β -GD activities were measured in 47 newborns with breastmilk jaundice and in 60 healthy newborns by using enzymological method.The positive ratesof milk and fecal β -GDmeasurement in babies with breast milk jaundice were analysed. Results Milk and fecal β -GD activities (1.363±0.299 U/L and 1.071±0.297 U/L)were significantly higher in infants with breast milk jaundice than those in healthyinfants (0.746±0.325 U/L and 0.496±0.276 U/L).The positive rates of milk β -GD measurement in infants withbreast milk jaundice and healthy newborns were 66.0% and 8.3% respectively.The differencebetween them was significant(P<0.01).Its sensitivity,specificity,positive predictingvalue,negative predicting value and correct diagnostic rate were 66.0%,91.7%,86.1%,77.5%and 80.4% respectively.The positive rates of fecal β -GD measurement in babies with breast milk jaundice andhealthy newborns were 68.1% and 6.7% respectively,the difference between them wassignificant(P<0.01).Its sensitivity,specificity,positive predicting value,negativepredicting value and correct diagnostic rate were 68.1%,93.3%,88.9%,78.9% and 82.2%respectively. Conclusion β -GD activity seems tobe an important factor in breast milk jaundice in neonates.Milk and fecal β -GD measurement may be useful fordiagnosis of breast milk jaundice.

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