周丛乐 张家洁 周林 冯琪 (100034 北京医科大学第一医院儿科)周丛乐 张家洁 周林 冯琪 中华围产医学杂志 1998 0 1 1


    关键词：婴儿；新生；脑缺氧；脑损害；慢性 期刊 zhwcyxzz 0 论 著 fur -->


    

(本课题受卫生部科学研究基金资助)

    

【摘要】 目的 了解新生儿缺氧后脑氧合功能状态。 方法 应用近红外光谱测定技术(NIRS)对39例有围产期缺氧史和42例无缺氧史的新生儿在安静状态下和声音刺激后脑的氧合功能进行了检测，并与脑电图和影像学检查进行了比较。 结果 正常新生儿在安静状态下脑氧合状态稳定，声音刺激后脑氧合增强，然而在有缺氧史的新生儿，显示出脑活动抑制，对声音刺激所产生的脑氧合反应性变化减弱。13例病例在监测过程中出现发作性脑氧合降低。 结论 在围产期缺氧性脑损伤后，脑氧合功能在一段时间内仍可能是异常的，这种变化与脑损伤程度有关。

    The Changes of Cerebral Oxygenation and its Relation to Severity of BrainDemage After NeonatalHypoxia Zhou Congle,Zhang Jiajie,Zhou Lin,et al. Departmentof pediatrics,First Hospital,Beijing Medical University,Beijing 100034

    【Abstract】 Objective To investigate neonatal cerebral oxygenationafter hypoxia. Methods Cerebral oxygenation of 39 babies withperinatal hypoxia and 42 neonates without hypoxia was observed under quiet state andstimulation of sound by Near Infrared Spectroscopy(NIRS) and compaired with the findingsof EEG and image studies. Results In normal neonates cerebraloxygenation was steady under quiet state,where as it increased after soundstimulation.However,newborns with hypoxia showed inhibited brain activities with littlechanges in cerebral oxygenation in response to sound stimuli.Episodes of deoxygenationwere found in 13 cases during monitoring. Conclusion After perinatalhypoxic brain damage,the function of cerebral oxygenation can be still abnomal for acertain period,which is related to the degree of brain damage.

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