董震 成效敏 王欢 顾玉东 中华手外科杂志 1999 0 15 2


    关键词：周围神经；神经再生；评价研究；动物；实验 期刊 zhswkzz 0 基础研究 fur -->


    

【摘要】 目的 比较周围神经损伤后端侧缝合与端端缝合方法疗效的优劣。 方法 SD大鼠12只，按手术先后随机分成A，B两个时间组。 左侧腓总神经切断后作端端缝合。 右侧腓总神经切断后,远断端与近断端上方0.5 cm 束外膜开窗处作自身端侧缝合。 分别于术后1、3个月时作肌电图后取材,测肌湿重及作组织学检查。 结果 A、B两组，端侧缝合与端端缝合比较，肌电图中诱发电位潜伏期延长、波幅降低。 胫前肌肌湿重减轻。 肌纤维截面积、有髓神经纤维数均减少。 经配对t检验，P值均 < 0.05。 结论 周围神经断伤作端侧缝合后，其神经再生质量不及端端缝合优良。

Comparison of the outcome of end - to - side neurorrhaphy and end - to - end neurorrhaphy of the peripheral nerves:an experimental study

DONG Zhen, CHENG Xiaomin, WANG Huan, et al. Department of Hand Surgery,Huashan Hospital,Shanghai Medical University, Shanghai 200040

【Abstract】 Objective To evaluate the results of end - to - side neurorrhaphy and end - to - end neurorrhaphy after peripheral nerve injury. Methods 12 SD rats were randomly divided into two groups, group A and group B, with 6 rats each. The left common peroneal nerve was repaired in an end - to - end coaptation after transection. The right common peroneal nerve was repaired in an end - to - side fashion, the distal end being sutured to the epineurial and perineurial window 0.5 cm proximal to the proximal end. Regeneration was tested via electromyographic examination,muscle wet weight measurement and histological examination at postoperative month one in group A and postoperative month three in group B. Results In both group A and group B, parameters obtained at the end - to - side neurorrhaphy side were inferior to those of the end - to - end repair. The neurorrhaphy side latency of the evoked potential was elongated. The amplitude of the evoked potential was lower. The wet weight and the cross sectional area of the anterior tibial muscle was smaller.The number of the myelinated nerve fibers was fewer. The difference was statistically significant (P < 0.05). Conclusions The quality of nerve regeneration in end - to - side neurorrhaphy was inferior to that in end - to - end neurorrhaphy.

     ......