关键词：婴儿；新生；脑缺氧；脑缺血；高糖血症
【摘要 】 目的 探讨新生儿缺氧缺血性脑病(HIE)应激性高血糖的发生情况及其临床意义。 方法 采用美国强生公司生产的ONETOUCH Ⅱ血糖仪及配套试纸对60例HIE患儿进行血糖监测。标本来自桡动脉血做完血气后所剩血液。 结果 发现入院时治疗前高血糖19/60例(32%)，其中轻度无一例高血糖，中度3/23(13%)重度16/18(89%)，中、重度相比差异有非常显著性(P<0.01)。重度HIE患儿治疗前血糖明显高于轻、中度差异有非常显著性(P均<0.01)；pH值和BE值均明显低于轻、中度(前者P均<0.05，后者P均<0.01)。且19例高血糖HIE患儿治疗前的血糖值与pH值、BE负值均呈显著负相关(前者P<0.05，后者P<0.01)。治疗前血糖越高，病死率越高。 结论 HIE患儿病情越重，应激反应越强烈，血糖升高越明显，脑细胞酸中毒越重，预后越差。因此，治疗前血糖测定可作为HIE患儿判断病情和预后的辅助的指标。
Hyperglycemia and itsClinical Significance in Newborn Infants with Hypoxic Ischemic Encephalopathy
LIN Xinzhu,HUANG Lifen, CAIDonggui, et al. Department of Pediatrics, Zhangzhou Municipal Hopital, Zhang zhou 363000
【Abstract 】 ObjectiveTo study the incidence and the clinical significance of stressing hyperglycemia in newborninfants with hypoxic ischemic encephalopathy (HIE). Methods The pretreated bloodglucose (BG) of 60 cases with HIE was tested with One Touch Ⅱ glucose meter beforetreatment. Results 19 of the 60 cases (32%) had hyperglycemia,3 of them with moderateHIE and 16 with severe HIE, while no hyperglycemia was found in the mild ones. Theincidence of hyperglycemia between the moderate cases and the severe cases was significantstatistically (P<0.01).The pretreated BG in the severe cases was obviously higher(P<0.01),and the pH value (P<0.05) and BE negative value(P<0.01) were much lower than thosein the mild and the moderate cases. The pretreated. BG had significantly negative relationwith the pH value (P<0.05) and BE (P<0.01) in the 19 cases of hyperglycemia. Thehigher pretreaed BG ......
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