姜正林 沈洪妹 杨凯 金淑仪 226001 江苏省，南通医学院航海医学研究所 中华航海医学杂志 1999 0 0 1


    关键词：生姜；东莨菪碱；山莨菪碱；运动病 期刊 zhhhyxzz 0 航海环境医学 fur -->


    

【摘要】 目的 了解不同途径使用生姜液的抗运动病效果并比较生姜与东莨菪碱和山莨菪碱抗运动病作用的强弱。方法 给大鼠旋转刺激，诱发异嗜高岭土行为(按高岭土摄食量判定运动病轻重程度)，观察各药剂对大鼠异嗜高岭土行为的抑制情况。结果 腹腔注射生姜液的大鼠，经旋转刺激后高岭土摄入量明显低于灌胃给药的大鼠。生姜与抗胆碱药的抗运动病效果无显著差异，而东莨菪碱与山莨菪碱的抗运动病作用强度相当。结论 腹腔注射生姜液的抗运动病作用强于灌胃给药。提示生姜抗运动病作用除与其对胃肠的直接作用有关外，可能还有其它作用机制。

    

    Observation of the effect of ginger and Ach-receptorinhibitors on simulated motion sickness in rats. JIANG Zhenglin, SHEN Hongmei, YANG kai, et al. Institute ofNautical Medicine, Nantong Medical College, Jiangsu 226001

     【Abstract】 Objective To observethe anti-motion sickness(AMS) effect of ginger juice administrated by different routes andcompare the AMS effect of ginger with two Ach-receptor inhibitors(scopolamine andanisodamine).Methods Rats werestimulated by method of rotation to induce kaolin paroxia as an expression of motionsickness and its severity was determined by the amount of kaolin eaten, then ginger juiceand Ach-receptor inhibitors were separately administrated to see how much each of thedrugs could reduce the amount of kaolin eaten.Results Ginger juice administrated intraperitoneally reduced the amount ofkaolin eaten more significant than when it was administrated orally; and the AMS effect ofginger was not significantly different from the two Ach-receptor inhibitors. Besides, theAMS effect of anisodamine was found equal to that of scopolamine.Conclusions The AMS effect of ginger adminstration intraperitoneally isstronger than when it is adminstered orally, which suggests that other mechanism may beinvolved in its AMS effect beside its direct gastro-intestinal action.

     【Key words】 Ginger Scopolamine Anisodamine Motionsickness

(Chin J Naut Med, 1999,6:20)

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