董文度 谢培增 王琰 张敏华 徐根兴 袁驾南 金淑仪 姜正林 李建成 庄坚 210099 南京，海军医学高等专科学校(董文度、谢培增、王琰、张敏华、徐根兴、袁驾南)；南通医学院(金淑仪、姜正林、李建成、庄坚) 中华航海医学杂志 1998 0 0 3


    关键词：运动病；前列腺素；Na+-K+-ATP酶；血栓素B2；6 期刊 zhhhyxzz 0 航海环境医学 fur -->


    

摘要 目的：研究运动病大鼠血浆TXB₂ 、6-keto-PGF_{1 α} 与毛细血管内皮细胞Na⁺ -K⁺ -ATP酶的变化规律及其内在联系，探讨运动病发生的机理。方法：采用放射免疫方法和图像分析系统，对运动病大鼠血浆TXB₂ 、6-keto-PGF_{1 α} 和小脑毛细血管内皮细胞Na⁺ -K⁺ -ATP酶进行自动检测和定量分析。结果：运动病组大鼠血浆TXB₂ 和6-keto-PGF_{1 α} 明显高于对照组(P<0.05或P<0.01)，而小脑毛细血管内皮细胞Na⁺ -K⁺ -ATP酶的活性则显著低于对照组(P<0.01)。结论：血浆中高浓度的TXB₂ 可能是运动病脑血管收缩，脑血流量减少的重要原因之一。脑内Na⁺ -K⁺ -ATP酶活力降低既是脑组织缺血缺氧的结果，又是加重运动病脑血流障碍的继发性原因。

    -酮-前列腺素F_{1 α}

Measurement of plasma prostaglandinand quantitative image analysis of Na⁺ -K⁺ -ATPase in cerebellum of rats with motion sickness Dong Wendu, Xie Peizeng, Wang Yan. et al. Department of Cytobiology, Naval Medical College, Nanjing 210099

     Abstract Abstract Aim: To study the rule and interrelationship of the changes of plasma TXB₂ ,6-keto-PGF_{1 α} and capillary endothelial cell Na⁺ -K⁺ -ATPase in rats with motion sickness, so as to explore the pathogenesis of motion sickness. Methods: TXB₂ and 6-keto-PGF_{1 α} in rats with motion sickness were measured by radio-immuno-assay and the capillary endothelial cell Na⁺ -K⁺ -ATPase activity in the cerebellum was measured by means of computer image analysis. Results: Blood plasma TXB₂ and 6-keto-PGF_{1 α} in the motion sickness group (MSG) were higher than that in the control group (P<0.05 or P<0.01); while the capillary endothelial cell Na⁺ -K⁺ -ATPase activity in the cerebellum of MSG rats was significantly lower than that of control group(P<0.01). Conclusion: The high concentration of TXB₂ in the blood plasma of the MSG rats might be one of the important causes of contraction of brain vessel and decrease of blood flow. The low Na⁺ -K⁺ -ATPase activity in the brain tissue is not only the result of brain ischemia and hypoxia, but also the secondary factor aggravating the cerebral blood flow obstruction in motion sicknees.

     Key words Key words Motion sickness Prostaglandin Na⁺ -K⁺ -ATPase Thromboxane B₂ 6-keto-PGF_{1 α}

(Chin J Naut Med , 1998,5:132)

为了对运动病的发病机理进行探索 ......