方虹 原田雅史 西谷 弘居丧 710032 西安，第四军医大学西京医院放射科(方虹)；日本德岛大学医学部放射医学教研室(原田雅史、西谷 弘) 中华放射学杂志 1999 0 33 4


    关键词：核磁共振；脑；弥散；代谢 期刊 zhfsxzz 0 中枢神经系统放射学 fur -->


    

【摘要】 目的 建立一种适应于临床研究脑内化合物分子弥散运动的磁共振质子波谱检测方法，并初步探讨脑灰、白质中分子运动的差异性。方法 采用激励回波探测序列(STEAM)分别对含纯水和丙酮的水模以及18例正常人脑进行测量，其中8例同时测量脑灰、白质。结果 弥散质子磁共振波谱可较好地反映出不同化合物弥散运动的差别。水模测量显示丙酮的弥散系数大于水。正常人脑测量显示N-乙酰门冬氨酸(NAA)在脑灰质中的弥散系数明显大于脑白质，分别为(0.214±0.089)×10^-2 mm² /s和(0.130±0.056)×10^-2 mm² /s，P<0.01。 胆碱 (Cho)和肌酸 (Cr) 分子的弥散灰白质无显著性差异 (P>0.05)。结论 作为一种新的检测方法，弥散磁共振波谱不仅可提供生物组织中生化代谢的信息，而且可反映微环境中分子弥散运动的情况，有助于理解和分析组织特性和病理生理变化。

The diffusion status of metabolites in human brain: measured by proton diffusion MR spectroscopy

FANG Hong^* , MASAFUMI Harada, HIROMUNishitani. ^* Department of Radiology, Xijing Hospital,the Fourth Military Medical University, Xi'an 710032

【Abstract】 Objective To develop a reliable approach to diffusion proton MR spectroscopy on human brain with clinical MR scanner and investigate the diffusion status of metabolites in gray and white matter. Methods Pure water, acetone phantom and 18 normal human brain were studied using stimulated echo acquisition mode(STEAM) diffusion proton MR spectroscopy. The diffusion condition of gray matter and white matter were investigated on eight subjects. Results Diffusion spectroscopy can reflect the difference of diffusion conditionsin water and acetone phantom accurately. In human brain, diffusion of NAA(N-acetyl-aspartate) in gray matter [(0.214±0.089)×10^-2 mm² /s] is significantly higher than that in white matter [(0.130±0.056)×10^-2 mm² /s](P<0.01). There is no significant difference of diffusion coefficients of creatine (Cr) and choline containing substances (Cho) between gray and white matter (P>0.05), although the mean values in gray matter is slightly higher than those in white matter. Conclusions In addition to providing the information about metabolites density in living tissue, the mobility information of the metabolites can be further added by diffusion MR spectroscopy, this may reflect intracellular environment and the characterization of tissue.

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