冯晓英 张海鹰 冯晓英 江苏省卫生防疫站；张海鹰 北京301医院实验外科 中国微生态学杂志 1999 0 11 5


    关键词：噬菌蛭弧菌；致病性大肠杆菌 期刊 zgwstxzz 0 论著 fur -->


    

摘 要 实验建立了致病性大肠杆菌E₀₁₁₁ 感染昆明小鼠动物模型，用噬菌蛭弧菌进行保护试验。致病性大肠杆菌E₀₁₁₁ 攻击前3天，用噬菌蛭弧菌预先保护，小鼠生存时间与对照组比较明显延长，存活率高(P<0.05)。致病性大肠杆菌E₀₁₁₁ 攻击后1小时，用噬菌蛭弧菌保护与对照组比较生存时间，存活率无差异(P>0.05)。并证明噬菌蛭弧菌8×10⁵ CFU/ml小鼠腹腔注射0.02ml/g对小鼠无毒性反应。

THE PRIMARY RESEARCH ON THE BDELLOVIBRIO BACTERIOVORUS

    FOR PROTECTING THE MICE FROM E.COLI

Feng Xiaoying,Zhang Haiying.Vibrio phage laboratory of Jiangsu province

    sanitart and Anti-Epidemic station Nanjing 210009

Abstract The animal model of the kunming mice infected with E.Coli₀₁₁₁ is developed.It demonstrated that active Bde-llovibrio bacteriovorus (8×10⁵ pfu/ml) that were injected intraperitoneally to the mice is not toxic.Being attacked with E.Coli₀₁₁₁ 3 days ago the mice were injected with Bdellovibrio bacteriovorus.The survive rate in Test group is higher than that in control group.There is significant differene (P< 0.05). Being atacked with E.Coli₀₁₁₁ one hour later,the mice were injected with Bdellovibrio bacteriovorus the survire rate in test group is lower than that in control group.There is no significant difference (P> 0.05).

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