林世和 宋晓南 赵节绪 江新梅 谷艳英 (白求恩医科大学第一临床学院神经内科， 长春 130021) 中国神经免疫学和神经病学杂志 1999 0 6 4


    关键词：Creutzfeldt-Jakob病；磁共振成像；脑活检 期刊 zgsjmyxysjbxzz 0 218-223 论 著 fur -->/info/meeting/meeting02.asp?keyword=神经病学


    

摘要 目的 探讨头部磁共振成像对Creutzfeldt-Jakob病(CJD)的诊断价值。方法 2例均经脑活检、免疫组化及实验鼠传递证实，分别于发病后2、12个月进行头部磁共振检查。结果 2例双侧尾核、壳核于T2加权像均呈对称性均质高信号。结论 头部磁共振成像的异常信号对CJD诊断虽非完全特异，但结合临床具有一定价值。

    中图号 R742.8

Magnetic Resonance Image Diagnosis of

    Creutzfeldt-Jakob Disease

Lin Shihe Song Xiaonan Zhao Jiexu Jiang Xinmei Gu Yangying

    ( Department ofNeurology, The First Teaching Hospital of Norman Bethune University of Medical Sciences,Changchun 130021 )

Objective To assess a diagnostic utility of imaging features of magnetic resonance images (MRI) ofpatients with Creutzfeldt-Jakob disease(CJD). Methods To review the MRIof two patients whose diagnosis of CJD had proved by immunohistochemical staining andexperimental animal transmission. The patients clinical findings were also analyzed. Results The two patients had MRI examinations on second and twelfth month respectively after theonset of symptoms. In all two patients the hyperintense sinal abnormalities in the caudatenuclei and basal ganglia on proton density and T2-weighted images were diffuse andbilaterally symmetric. Conclusions Signal abnormality in the basalganglia and caudate nuclei on MR imagings may be a specific sign of Creutzfeldt-Jakobdisease and could be helpful in confirming the diagnosis of CJD.

     Key words Creutzfeldt-Jakob disease; magnetic resonance image; brain biopsy

英国发表了疯牛病与Creutzfeldt-Jakob病(CJD)有重要联系以来 ......

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