【摘要】目的 探讨非小细胞肺癌中抗CD₃₄ 单抗标记的血管生成的表达状况。方法 采用免疫组化法检测81例手术切除的非小细胞肺癌标本中抗内皮细胞表面抗原CD₃₄ 单抗标记的血管生成。结果 CD₃₄ 以其染色的特异性、敏感性及清晰的背景而易于识别。统计学分析显示微血管密度同肺癌临床分期的进展有密切关系(P<0.05)，但与淋巴结转移及其它临床病理特征无明显关系(P>0.05)。结论 肺癌中微血管密度在肺癌的发生、发展中可能起重要作用。

    【中图分类号】R734.2；R730.3

Expression of angiogenesis labelled by anti-CD34 monoclonal antibody in non-small cell lung cancer

ZHU Bing,WEN Jianhu

    (Department of Thoracic Surgery,The First Hospital,Chongqing University of Medical Science,Chongqing 400016,P.R.China)

【Abstract】Objective To determinethe expression of angiogenesis labelled by anti-CD34 monoclonal antibody in non-small celllung cancer.Methods Immunohistochemical detection for tumor-associated microvessels wasperformed to 81 non-small cell lung cancer tissues using anti-CD34 monoclonal antibodiesdirected against endothelial markers.Results Staining of CD34 was easy to identifybecause of its specificity,sensitivity and clear background.Statistic analysis showed thatthe microvessel count was significantly related to the TNM staging but not to lymph nodemetastasis and other clinicopathologic characteristics.Conclusion MVD may play animportant role in the oncogenesis and development of lung cancer.

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