杨 隽 吴黎昌 胡 莹 董妙珠 李建敏 郑勇英 叶于薇 仲伟鉴 上海市卫生防疫站 (200335) 中国食品卫生杂志 1999 0 0 3


    关键词：保健食品；高血压；肾血管性；大鼠；WISTAR 期刊 zgspwszz 0 论著 fur -->


    

摘 要 为提供新的保健食品功能检测方法，建立肾动脉狭窄型高血压大鼠模型。采用二肾一夹法复制肾性高血压大鼠模型，使肾性高血压造模手术组血压均显著升高。服用大蒜制剂后，肾性高血压大鼠血压降低，而对大鼠体重增长值和心率没有明显影响。结果表明肾动脉狭窄型高血压造模方法灵敏可靠，可以应用在保健食品的功能学评价中。

The application ofrenovascular hypertension model to blood pressure regulatory action of healthy foods/YangJun Wu Lichang Hu Ying et al.//Chinese Journal of Food Hygiene.-1999,11(3):6～7

    To establish the renovascular hypertension model of rat and use forevaluating the blood pressure regulatory function of health food,the renovascularhypertension model of rats was established by using two-kidney one clip(2K1C) method.After four weeks, the blood pressure in 2K1C rats increased significantly comparing withcontrolled group. Continuous administration of a health food sample to hypertension ratscould decreased the blood pressure significantly, and there was little effects on theweight growth and heart rates of the rats. It was suggested that the operation method ofrenovascular hypertension model established by 2K1Cmethod is sensitive and valid. It couldbe utilized in evaluating the blood pressure regulatory action of health foods.

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