关键词:副结核杆菌;克隆病;致病菌
摘要 目的 探讨副结核杆菌(MP)在克隆病(CD)病因学中的作用。
方法 将MP接种地鼠。诱导肉芽肿性肠炎动物模型,然后用一部分CD肠粘膜匀浆作PCR扩增MP,另一部分肠壁接种地鼠。
结果 MP接种8月后,有80%(16/20)出现肉芽肿性改变,PCR阳性CD匀浆肠壁接种4月后,有5只出现肉芽肿性改变,与MP组的病理改变相似。PCR阴性CD匀浆组有一只出现肉芽肿性改变。
结论 MP可能为部分CD的致病菌,但并非唯一的致病因素。
COMPARATIVE STUDY OF ENTERITIS INDUCED BY
MYCOBACTERIUM PARATUBERCULOSIS AND TISSUE HOMOGENATES OF CROHN'S DISEASE IN HAMSTERS
Miao Yinglei OuyangQin Gan Huatian
(Department of Gastroenterology,The First Affiliated Hosptal of Kun ming MedicalCollege,Kunming 650032)
ABSTRACT Aim A comparison of the macroscopical and histolog ical appearance ingranulomas was made induced by Mycobacterium Paratuberculosis (MP) and Crohn's Disease(CD)tissue in hamsters,in order to investigate whether MP plays an etiologic role in CD .
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