张鑫奎 王涛 邓群 陆江阳 张鑫奎 王涛 邓群(中国人民解放军三O四医院普通外科 100037 北京)；陆江阳(病理科) 中国胃肠外科杂志 2000 0 3 4


    关键词：纤维蛋白组织粘着剂；胶原；吻合口瘘 期刊 zgwcwkzz 0 240-242 论 著 fur -->


    

【摘要】目的观察小肠切除、肠吻合后局部用国产纤维蛋白粘合剂在促进吻合口愈合、预防吻合口瘘中的作用。方法实验动物随机分为两组，对照组兔在肠切除吻合后表面喷涂生理盐水，实验组喷涂纤维蛋白粘合剂。术后第1、3、7、14d切取含吻合口的肠管，分别测定肠吻合口破裂压、吻合口组织羟脯氨酸和胶原量。结果术后两组动物均无吻合口瘘，术后第1、3d，实验组兔肠吻合口破裂压高于对照组(约5mmHg)，局部肠组织羟脯氨酸、胶原量也多于对照组，但差异不显著。结论纤维蛋白粘合剂可促进成纤维细胞增殖和胶原合成，对预防吻合口瘘有一定意义。

Experimental study of fibrinsealant on preventing intestinal anastomotic leakage

ZHANG Xinkui,WANG Tao,DENG Qun,et al.

    Department of General Surgery， 304th Hospital of PLA,Beijing 100037,China

【 Abstract】 Objective To evaluate the effect of fibrinsealant used at anastomotic site for preventing intestinal anastomotic leakage.MethodsFive-centimeter segments of rabbits ileum were resected,then all animals were divided intotwo groups.In control group,normal saline was used on the surface of anastomoticsite,meanwhile fibrin sealant was used in experimental group.Relaparotomy of all rabbitswas performed in day 1,3,7,14 postoperatively. Anastomotic burstingpressure(ABP),hydroxyproline and collagen content of the tissue at anastomotic site weremeasured. Results The ABP of control group was about 5 mmHg lower than that ofexperimental group in day 1 and 3 postoperatively. The hydroxyproline concentration of thetissue at anastomotic site increased in experimental group compared with the controlgroup. In experimental group,collagen content at the anastomotic site increased slightlyin day 3 and 7. Conclusion Fibrin sealant can facilitate fibroblast proliferation andcollagen synthesis to promote anastomosis healing.

【 Key words】 Fibrin sealant; Collagen; Anastomotic fistula

肠切除、肠吻合是腹部外科常用的手术方式 ......