关键词：吗氯贝胺；丙咪嗪；抑郁症
摘要 目的：采用吗氯贝胺和丙咪嗪治疗抑郁症的双盲对照试验，同时对吗氯贝胺进行开放临床研究。方法：15对双盲和30例开放的临床研究，采用疗前和疗后第1，2，4，6周末进行HAMD，HAMA，TESS及CGI的评定。结果：吗氯贝胺组、丙咪嗪组、吗氯贝胺开放组HAMD减分率分别为69.3%，83.6%，75.6%，前二者经统计学分析组间无差异性(P>0.05)；各组内治疗前后HAMD得分均有差异性(P<0.05)。3组显效率分别为80%，93.3%，90%，前二者经统计学分析组间无差异性(P>0.05)。3组出现的不良反应基本相似。结论：吗氯贝胺是一种安全、有效的抗抑郁药，值得推广使用。
A RANDOMIZEDDOUBLE BLIND CONTROLLED STUDY ON THE EFFEICACY OF MOCLOBEMIDE AND IMIPRAMINE IN TREATMENTOF DEPRESSION
Fan Jianxiong, Gu Shifen
(Department of Brain,Nanjing Medical Univercity,Nanjing 210029)
ABSTRACT OBJECTIVE: In comparison toeffect of moclobemide and I mipramine treating depression.METHODS: 15 pares were givn bydouble-blind research and 30 cases we re by open research. Effect was valued by HAMA,HAMD, CGI and safety was valued by TESS at 2,4,6 weekend of after treating and beforetreating. RESULTS: Decrease rate of HAMD in moclobemide group was 69.3% and in imipraminegroup was 83.6%. There was no difference of decrease rate of HAMD b et ween two groups instatistics (P>0.05). There was a significant difference o f HAMD total score betweenbefore treating and after treating in two groups (P <0.05). Significant improvementrate was 80% in moclobemide group and 93.3 % in imipramine group. There was no differenceof improvement rate between two grou p s. Decrease rate of HAMD was 75.6% and improvementrate was 90% in moclobemide open group. Side effect were similar among above three groups.CONCLUSION: Moclobemide is a safe and effective anti-depressive drug and it is worthy ofwidely usement.
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