赵继宗 詹文华 陈规划 詹皇南 王吉甫 (赵继宗，詹皇南)510080 广州，中山医科大学附属第一医院外科实验室；(詹文华，王吉甫)胃肠胰外科；(陈规划)器官移植外科 中国胃肠外科杂志 1999 0 2 3


    关键词：肿瘤抗原；消化系统肿瘤；诊断应用 期刊 zgwcwkzz 0 论 著 fur -->


    

【摘要 】 目的 探讨国人血清肿瘤标志物-肿瘤相关糖蛋白-72(tumor-associated glycoprotein, TAG-72)的水平变化在消化系统恶性疾病诊断中的意义。方法 采用抗双位点固相免疫放射分析法对健康人155例、消化系统恶性和良性疾病患者共671例检测其血清TAG-72的水平，后2组同时检测癌胚抗原(CEA)和糖抗原19-9(CA19-9)水平进行综合分析。结果 健康成人155例正常参考值上限：40岁以下≤4.5 kU/L，41岁以上≤5.6 kU/L，两组差异有极显著意义(P<0.001)；各组肿瘤患者检出阳性率在14.6%～38.1%之间，在消化系统良性疾病中的假阳性率仅为2.8%。将本法与CEA、CA19-9联用，对胃癌、结直肠癌、胰腺癌的诊断敏感性分别提高到72.0%、59.4%和90.5%。结论 血清TAG-72检测具有重要的临床应用价值，并且与CEA、CA19-9之间在诊断上有很好的互补性。

A clinical study of tumor associated glycoprotein-72 in human serum

ZHAO Jizong, ZHAN Wenhua, CHEN Guihua, et al. Department of Surgery, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, 510080

【Astract 】 Objective To explore the relationship between serum tumor associated glycoprotein-72(TAG-72) and diagnosis of the digestive malignant disease in a Chinese population. Methods Serum samples from 155 healthy adults and 671 patients with digestive system benign or malignant diseases were examined for level of TAG-72 with anti-dual-point solid immunoradiometric assay. The serum samples from the latter two groups were examined for level of carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA 19-9) at the same time. Results The uppermost concentration of serum TAG-72 in 155 healthy adults was ≤4.5 kU/L below the age of 40 and ≤ 5.6 kU/L above the age of 41. The positive rate of digestive system carcinoma patients was between 14.6% and 38.1%. Only 2.8% of 215 samples from patients with benign digestive disease was over the normal referent value. When TAG-72 was combined with CEA and CA19-9, sensitivity in gastric, colorectal and pancreatic cancer was elevated to 72.0%, 59.4%, and 90.5%, respectively. Conclusion Detecting serum TAG-72 level is of great value to clinical application. There is a diagnostic complementation between TAG-72, CA19-9 and CEA.

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