许珂 张永亮 李晓帆 郁缪宇 刘协和 许珂(广州市精神病医院，现华西医科大学附一医院精神科，610041)；张永亮(华西医科大学法医学系)；李晓帆 郁缪宇 刘协和(华西医科大学附一院精神科) 中国神经精神疾病杂志 2000 0 26 3


    关键词：抗抑郁药；5-HT；免疫反应 期刊 zgsjjsjbzz 0 159-160 论著与学术交流 fur -->


    

【摘要】目的 进一步探讨抗抑郁药对5羟色胺(5-HT)的作用。方法 采用免疫组织化学方法，对一次和长期给予4种抗抑郁药的大鼠进行研究。结果 ①一次给药后，仅氟西汀降低大鼠海马和丘脑5-HT免疫反应性；②长期给药组中，4种抗抑郁药均能降低大鼠额叶、海马、丘脑、脑干和小脑的5-HT免疫反应性。结论 抗抑郁药可能不同程度地抑制5-HT再摄取，减少细胞内5-HT浓度。

5-HTimmunoreaction decreases in several regions of rat brain induced by antidepressants.

Xu Ke, Li Xiaofan, Yu Liuyu, Zhang Rongliang and Liu Xiehe.

    (Department of Psychiatry, The First Affiliated Hospital, WCUMS, 7 Xiaoxue Road,Chengdu.610041. Tel: 028-5551255, 5422633)

【Abstract】ObjectiveToinvestigate the effect of antidepressant drugs on serotonin (5-HT).Methods 5-HTimmunoreaction in rats brain was detected after the acute and chronic adminisstration offour antidepressant drugs by immunohistochemistry methos.Results The results showedthat: (1) Only fluoxetine could decrease the 5-HT immunoreaction in cornu ammonis andthalamas in rat brain in the acute group; (2) Four antidepressant drugs could decrease5-HT immunoreaction in six regions of rats brain in the chronic group. Conclusions Itwas suggested that four antidepressants might inhibit 5-HT reuptake in various degrees anddecrease the 5-HT concentrations in intraneuron.

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