赖淑珍 陈金弟 黄继真 王春云 陈登其 魏永超 福建南平解放军92医院(353000) 中国神经精神疾病杂志 1999 0 0 1


    关键词：精神分裂症；自身抗体 期刊 zgsjjsjbzz 0 论著与学术交流 fur -->


    

【摘要】 目的 探讨精神分裂症与自身抗体的关系。方法 测定了精神分裂症100例，正常人61人的血清抗甲状腺球蛋白抗体(TGA)、抗甲状腺微粒体抗体(TMA)、抗心磷脂抗体(ACA)，抗脑抗体(ABAb)和抗胰岛素抗体。结果 精神分裂症患者血清自身抗体阳性率均偏高；总阳性率为66%，有2种以上自身抗体者占46%，均明显高于正常人(P<0.05)。结论 精神分裂症存在自身免疫倾向；自身抗体在精神分裂症的发病机制中，可能起重要作用。

    Schizophrenia and autoantibodies. Lai Shuzhen,Chen Jindi,HuangJiahen,Wan Chunyun, Chen Dengqi, Wei Rongchao. The 92 th Hospital of PLA,Nanping,Fujian. 353000.Tel:0599-8827755

    【Abstracts】 Objective To investigate the relationshipbetween schizophrenia and autoantibodies.Methods The antibodies of antithyroglobulin(TGA), antithyroid microsome (TMA), anticuorin(ACA), antibrain(ABAb) and anti-insulin(IAb) in serum of 100 patients with schizophrenia and 61 normal controls weredetected.Results The positiveness of the autoantibodies in serum of thepatients was 66% and 46% of them had more than one of the autoantibodies,both of whichwere significantly higher than that of the normal controls.Conclusions Thereis a tendency of autoimmunity in the patients with schizophrenia.Autoantibodies may playan important role in the pathogenisis of schizophrenia.

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