关键词：精神分裂症；抗精神病药；白细胞介素；疗效；免疫
【摘要】 目的 探讨典型、非典型抗精神病药对精神分裂症白细胞介素(IL)的影响及其与疗效之间的关系，以及免疫状态与精神症状的关系。方法 采用随机、双盲法应用固定剂量的利培酮和氟哌啶醇对78例慢性精神分裂症进行12周治疗，并在治疗前后评定PANSS量表。以18例健康人为对照。同时在治疗前后测定血浆IL-2、IL-6和IL-8含量。结果 ①利培酮和氟哌啶醇治疗均降低精神分裂症过高的IL-2水平，两者之间无明显差异。②两种药物对患者过高的IL-6、IL-8水平均无明显影响。③治疗前IL-2、IL-8越低，则疗效越好。④治疗后IL-8水平与精神症状、主要是阳性症状有关。结论 非典型和典型抗精神病药对精神分裂症免疫应答产生一定程度的抑制作用，两者之间无明显差异；患者治疗前的免疫水平与疗效之间存在一定的关系。
Theeffect of risperidone and haloperidol treatment on plasma interleukin 2, 6, 8 ininpatients with schizophrenia and their relationship to outcome
Zhang Xiangyang Zhou Dongfeng Shen Yucun Zhang Peiyan
( Institute of MentalHealth, Beijing Medical University, Beijing 100083. Tel:010-62091960, email: zhangxy @public. fhnet. cn. net )
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Abstract 】 Objective The purpose of the studywas to explore the effect of atypical and typical antipsychotic medications on plasmainterleukin 2, 6 and 8 and their relationship with outcome. Methods 78 chronic inpatientswith schizophrenia were treated with a fixed dosage of risperidone or haloperidol for 12weeks in a double-blind randomized design. PANSS scale was rated before and aftertreatment. Plasma interleukin 2, interleukin 6 and interleukin 8 were measured at baselineand endpoint, as compared with 18 normal controls. Results 1. Either risperidone or haloperidol treatment reduced theenhanced IL-2 level with no significant difference; 2. The two medications did not producesignificant influence on the elevated IL-6 and IL-8 levels. 3. Those patients with thelower baseline plasma IL-2and IL-8 levels had a better outcome. 4. There was significantpositive correlation between IL-8 level at endpoint and psychotic symptom, especiallypositive symptom. Conclusions Typical and atypical antipsychotic medications may inhibitthe immune response in schizophrenia to some extent, but there was no significantdifference between them. There may be a relationship between the immune function atbaseline and outcome. Additionally, a significant correlation may exist between IL-8 leveland psychopathology, or between IL-2 level and outcome.【 Key words 】 SchizophreniaAntipsychotic agent Interleukin Outcome Immunology ▲
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