关键词：血管内皮细胞生长因子；肢体缺血；基因治疗
涂兵 综述 金立人 审校
【摘要】 目的 探讨血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)基因治疗严重慢性肢体缺血性疾病的可能性。方法 综述近年来对有关VEGF的分子生物学、VEGF的促血管生成机理及通过基因转移表达VEGF改善缺血肢体血供所进行的研究。结果 临床前的研究显示，VEGF能够刺激动物缺血肢体侧支动脉的形成，即所谓的“治疗性的血管生成”； 临床结果证实，通过基因转移表达的VEGF能够促进新生血管形成，使有严重肢体缺血的患者预后明显改善。结论 这项生物技术将为那些药物治疗无效和不适于外科血管重建或置换术的严重肢体缺血性疾病患者提供一种新的治疗方法。
【中图分类号】 R654.4； Q789 【文献标识码】 A
【文章编号】 1007-9424(2000)03-0202-03
ADVANCE IN VASCULAR ENDOTHELIUM GROWTH FACTOR AND
VASCULAR ENDOTHELIUM GROWTH FACTOR GENE THERAPY
FOR PATIENTS WITH LIMB ISCHEMIA
TU Bing, JIN Li-ren.
( Department of General Surgery, The First Affiliated Hospital,
West China University of Medical Sciences, Chengdu 610041 )
【 Abstract 】 Objective To review the studies on vascular endothelium growth factor (VEGF) gene therapy for patients with chronic critical limb ischemia. Methods Advance in molecular biology of VEGF, mechanism of new vessel formation induced by VEGF and achievement of improving blood flow in patients with critical limb ischemia due to VEGF expressed by gene transfer in recent years has been reviewed in this article. Results Preclinical studies showed that VEGF can stimulate the development of collateral arteries in animals with limb ischemia, a concept called “ therapeutic angiogenesis ” , clinical results demonstrated that VEGF expressed by gene transfer can promote new vessel formation in patients with critical limb ischemia and improve significantly the prognosis for them. Conclusion VEGF gene transfer provide a novel treatment strategy for patients with critical limb ischemia, who neither had favorable response to phamarcological treatment nor were suitable for surgical reconstruction or revascularization.
【 Key words 】 Vascular endothelium factor Limb ischemia Gene therapy ▲
由动脉阻塞引起的肢体缺血性疾病日渐增多 ......
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