王世文 黄华新 何津春 宋爱琳 寇治民 (王世文，黄华新，宋爱琳，寇治民)730030 兰州，兰州医学院附属第二医院普通外科；(何津春)兰州医学院附属第一医院检验科 中国胃肠外科杂志 1999 0 2 3


    关键词：急性缺血性肠病；早期诊断；血清酶 期刊 zgwcwkzz 0 论著 fur -->


    

【摘要 】 目的 观察家兔急性肠缺血时的血清酶及生化变化。方法 采用肠系膜动、静脉血管结扎法复制家兔急性缺血性肠病的模型，根据肠组织缺血的四个不同程度的缺血期，分别抽取外周静脉血，测定CPK、CK-MB、LDH、LA、CRP和CO₂ CP的活性及其相应的变化规律。结果 CPK、CK-MB、LDH、LA、CRP活性随肠缺血时间的延长、缺血程度的加重而逐渐升高，而CO₂ CP则不断下降，与对照组相比，P<0.01。结论 上述指标可作为急性肠缺血疾病早期诊断的新方法，对判断腹腔内肠缺血状态是有效的和敏感的。

Changes of serum enzymesand some biochemical indices in acute intestinal ischemia

WANG Shiwen, HUANG Huaxin, HE Jinchun, et al. Department of Surgery ,Second Affiliated Hospital, Lanzhou MedicalCollege, Lanzhou 730030

【Abstract 】 Objective To investigate the changes ofserum enzyme level and biochemical indices in acute intestinal ischemia (AII) of rabbits. Methods Experimental animal models of AIIwere made by ligation of mesenteric arteries and veins on rabbits. The ischemic stateswere divided into 4 stages arbitrarily as initial(A, blood sampling immediately afterligation),mild(B),moderate(C)and severe(D).The serum level of CPK,CK-MB,LA,LDH,CRP and CO₂ CPof the experimental models at different stages and that of the controls were measured. Results The serum levels ofCPK,CK-MB,LA,LDH,CRP in experimental animal models were significantly increased(P<0.01),while the CO₂ CP were decreased (P<0.01) as compared with that ofcontrol. Conclusion The above enzyme and biochemical indices may be useful for earlydiagnosis of AII.

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