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关键词：乳腺癌；可溶性白细胞介素-2受体
摘要 为探讨血清可溶性白细胞介素-2受体(sIL-2R)水平与乳腺癌的分期和预后的关系，采用ELISA法对37例乳腺癌患者手术前后血清sIL-2R进行检测，同期检测了13例乳腺良性疾病患者及40例正常人血清sIL-2R水平。结果：乳腺癌患者血清sIL-2R明显高于乳腺良性疾病组和正常对照组，其术后20天血清sIL-2R水平明显低于术前；乳腺癌患者血清sIL-2R水平与临床分期密切相关，Ⅲ期患者明显高于Ⅰ、Ⅱ期，且术后20天仍保持在较高水平上。由此提示，血清sIL-2R的表达水平与乳腺癌患者的临床分期和预后密切相关，可作为鉴别乳腺良恶性疾病的一项参考指标。
INVESTIGATION OF PREOPERATIVE AND POSTOPERATIVESERUM SOLUBLE INTERLEUKIN-2 RECEPTOR IN PATIENTS WITH BREAST CANCER
Chen Jiansi, Chen Hanhua, Liu Jianlun, et al.
Cancer Hospital of Guangxi Medical University, Nanning 530021
Abstract To investigate therelationship between the serum soluble interleukin-2 receptor (sIL-2R) and the stage andprognosis of breast cancer. Using the method of sandwich ELISA, the preoperative andpostoperative sIL-2R in 37 cases of breast cancer was measured, 13 patients with benigndisease of breast and 40 normals were also measured. The serum sIL-2R levels in patientswith breast cancer were significantly higher than that of the benign disease of breast andthe normal controls. The serum sIL-2R about twenty days after operation was significantlylower than that before operation. The sIL-2R in patients with breast cancer wascorrelative to the clinical stage. The serum sIL-2R in stage Ⅲ patients was remarklyhigher than both stage Ⅰ and Ⅱ, its sIL-2R about twenty days after operation remainedin a high level. This results showed that expression of the serum sIL-2R is correlative tothe clinical stage and prognosis of the patients with breast cancer, it can be used as amarker of differentiating the benign from malignant disease of breast.
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