关键词:胃肿瘤;增殖细胞核抗原;预后
摘要 为了解增殖细胞核抗原(PCNA)在胃肿瘤中的表达及其临床意义,应用免疫组化技术(ABC法),对胃肿瘤(胃腺瘤性息肉10例,胃癌94例)组织切片中PCNA含量进行半定量检测。结果:①胃粘膜不同病理状态下PCNA指数差异有极显著性意义(P<0.01); ②PCNA指数与患者的性别和年龄无关(P>0.05),而与肿瘤的生长方式、组织类型、浆膜层受侵与否、淋巴结转移与否和临床分期关系密切(P<0.05);③PCNA指数与胃癌的预后密切相关(P<0.05),弱级(Ⅰ~Ⅱ级)表达的患者预后好。由此表明,PCNA检测可作为判断胃癌生物学行为和预后的良好指标之一。
EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGENIN HUMAN GASTRIC NEOPLASM AND ITS CLINICAL SIGNIFICANCE
Wang Kang, Sun Xuejun, Jia Zongliang, et al.
Department of General Surgery, First Affiliated Hospital, Xi′an Medical University, Xi′an 710061
Abstract To study the expressionof proliferating cell nuclear antigen (PCNA) in human gastric neoplasm and its clinicalsignificance. The expression of PCNA was semiquantitatively analysed immunohistochemically(ABC) in 10 gastric adenomatous polyp and 94 gastric carcinomas. Results: ①PCNA labelingindex (LI) showed a significant differentiation in different pathologic state (P<0.01) ......
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